Endostatin induces normalization of blood vessels in colorectal cancer and promotes infiltration of CD8+ T cells to improve anti-PD-L1 immunotherapy.

Chu, Xiao-Dong; Bao, Hui; Lin, Yu-Jian; Chen, Ruo-Xi; Zhang, Yi-Ran; Huang, Ting; He, Jia-Shuai; Huangfu, Shu-Chen; Pan, Yun-Long; Ding, Hui

Chu, Xiao-Dong; Bao, Hui; Lin, Yu-Jian; Chen, Ruo-Xi; Zhang, Yi-Ran; Huang, Ting; He, Jia-Shuai; Huangfu, Shu-Chen; Pan, Yun-Long; Ding, Hui.

Afiliación

Chu XD; Department of General Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.
Bao H; Department of Plastic Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.
Lin YJ; Department of General Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.
Chen RX; Department of Plastic Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.
Zhang YR; Department of General Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.
Huang T; Department of Clinical Pathology, First Affiliated Hospital of Jinan University, Guangzhou, China.
He JS; Department of General Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.
Huangfu SC; Department of General Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.
Pan YL; Department of General Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.
Ding H; Department of General Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.

Front Immunol ; 13: 965492, 2022.

Article en En | MEDLINE | ID: mdl-36389685

Asunto(s)

Neoplasias Colorrectales; Endostatinas; Ratones; Animales; Humanos; Endostatinas/metabolismo; Factor A de Crecimiento Endotelial Vascular/metabolismo; Inhibidores de Puntos de Control Inmunológico; Linfocitos T CD8-positivos/metabolismo; Inmunoterapia; Factores Inmunológicos/metabolismo; Inhibidores de la Metaloproteinasa de la Matriz; Factor de Crecimiento Transformador beta/metabolismo; Neoplasias Colorrectales/tratamiento farmacológico; Neoplasias Colorrectales/metabolismo

Palabras clave

CD8+ T cells; PD-L1 inhibitor; colorectal cancer; recombinant human endostatin; tumor vascular normalization

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Endostatinas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

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