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The case for FAT10 as a novel target in fatty liver diseases.
Wimalarathne, Madushika M; Wilkerson-Vidal, Quiana C; Hunt, Emily C; Love-Rutledge, Sharifa T.
Afiliación
  • Wimalarathne MM; Department of Chemistry, The University of Alabama in Huntsville, Huntsville, AL, United States.
  • Wilkerson-Vidal QC; Department of Chemistry, The University of Alabama in Huntsville, Huntsville, AL, United States.
  • Hunt EC; Department of Chemistry, The University of Alabama in Huntsville, Huntsville, AL, United States.
  • Love-Rutledge ST; Department of Chemistry, The University of Alabama in Huntsville, Huntsville, AL, United States.
Front Pharmacol ; 13: 972320, 2022.
Article en En | MEDLINE | ID: mdl-36386217
Human leukocyte antigen F locus adjacent transcript 10 (FAT10) is a ubiquitin-like protein that targets proteins for degradation. TNFα and IFNγ upregulate FAT10, which increases susceptibility to inflammation-driven diseases like nonalcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC). It is well established that inflammation contributes to fatty liver disease, but how inflammation contributes to upregulation and what genes are involved is still poorly understood. New evidence shows that FAT10 plays a role in mitophagy, autophagy, insulin signaling, insulin resistance, and inflammation which may be directly associated with fatty liver disease development. This review will summarize the current literature regarding FAT10 role in developing liver diseases and potential therapeutic targets for nonalcoholic/alcoholic fatty liver disease and hepatocellular carcinoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza