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[The influence of pyelovenous reflux on the development of acute pyelonephritis in an experimental model].
Akhmedov, O R; Magomedov, D M; Akhmedov, S R; Sargsyan, Sh M; Pulbere, S A; Kotov, S V.
Afiliación
  • Akhmedov OR; Pirogov Russian National Research Medical University Ministry of Health of Russia, Moscow, Russia.
  • Magomedov DM; N.I. Pirogov City Clinical Hospital 1 of the Moscow Healthcare Department, Moscow, Russia.
  • Akhmedov SR; I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
  • Sargsyan SM; Pirogov Russian National Research Medical University Ministry of Health of Russia, Moscow, Russia.
  • Pulbere SA; N.I. Pirogov City Clinical Hospital 1 of the Moscow Healthcare Department, Moscow, Russia.
  • Kotov SV; I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Urologiia ; (5): 23-28, 2022 Nov.
Article en Ru | MEDLINE | ID: mdl-36382813
INTRODUCTION: currently, endoscopic methods are the main option for surgical treatment of patients with urolithiasis (ICD). The widespread use of these operations has led to the development of a number of specific complications associated with the technology of their implementation. One of the frequent complications is the development of postoperative acute pyelonephritis against the background of intraoperative pyelovenous reflux. THE PURPOSE OF THE STUDY: to study under experimental conditions the severity of pathomorphological changes in the ureter and kidney tissue against the background of pyelovenous reflux in the presence and absence of bacterial flora. MATERIALS AND METHODS: 32 mature female rabbits of the "White Giant" breed were selected as an experimental model. Experimental strain of the E. Coli microorganism 105 KOE/ml. Laboratory animals were divided into 4 groups, 1-3 experimental groups, 4 control group of observation without surgical intervention. In experimental groups, NaCl 0.9% 2.0 ml was injected into the ureteral lumen in group 1, E. Coli 1x105 CFU/ml 1.0 ml in group 2, NaCl 0.9% 1.0 ml + E. Coli 1x105 CFU/ml 1.0 ml in group 3. RESULTS: Results: according to the results of the study, the pathomorphological evaluation of kidney and ureter preparations revealed pronounced inflammatory changes in group 3. CONCLUSIONS: pyelovenous reflux does not independently lead to the development of acute pyelonephritis. The combination of reflux and microbial flora leads to inflammatory changes in the wall of the calyx-pelvic system with the development of acute pyelonephritis, which is confirmed by the results of pathomorphological examination of kidney and ureter tissue.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pielonefritis / Reflujo Vesicoureteral Límite: Animals Idioma: Ru Revista: Urologiia Asunto de la revista: UROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Rusia
Buscar en Google
Añadir a Mi BVS
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pielonefritis / Reflujo Vesicoureteral Límite: Animals Idioma: Ru Revista: Urologiia Asunto de la revista: UROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Rusia