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Long-term oncologic outcomes of robot-assisted radical cystectomy: update series from a high-volume robotic center beyond 10 years of follow-up.
Bravi, Carlo A; Piazza, Pietro; Mazzone, Elio; Dell'Oglio, Paolo; Rosiello, Giuseppe; Martini, Alberto; Stabile, Armando; Moschini, Marco; Amato, Marco; Sarchi, Luca; Peraire, Maria; Farinha, Rui; Scarcella, Simone; Puliatti, Stefano; Knipper, Sophie; Berquin, Camille; Develtere, Dries; Sinatti, Celine; Van Puyvelde, Hannah; De Groote, Ruben; De Naeyer, Geert; D'Hondt, Frederiek; Schatteman, Peter; Briganti, Alberto; Montorsi, Francesco; Mottrie, Alexandre.
Afiliación
  • Bravi CA; Division of Oncology/Unit of Urology, URI; IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, Via Olgettina 60, 20131, Milan, Italy. carloandrea.bravi@gmail.com.
  • Piazza P; Department of Urology, Onze-Lieve-Vrouwziekenhuis Hospital, Aalst, Belgium. carloandrea.bravi@gmail.com.
  • Mazzone E; ORSI Academy, Ghent, Belgium. carloandrea.bravi@gmail.com.
  • Dell'Oglio P; Department of Urology, Onze-Lieve-Vrouwziekenhuis Hospital, Aalst, Belgium.
  • Rosiello G; ORSI Academy, Ghent, Belgium.
  • Martini A; Division of Urology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Stabile A; Division of Oncology/Unit of Urology, URI; IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, Via Olgettina 60, 20131, Milan, Italy.
  • Moschini M; Department of Urology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Amato M; Department of Urology, Antoni Van Leeuwenhoek Hospital, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Sarchi L; Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Peraire M; Division of Oncology/Unit of Urology, URI; IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, Via Olgettina 60, 20131, Milan, Italy.
  • Farinha R; Division of Oncology/Unit of Urology, URI; IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, Via Olgettina 60, 20131, Milan, Italy.
  • Scarcella S; Division of Oncology/Unit of Urology, URI; IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, Via Olgettina 60, 20131, Milan, Italy.
  • Puliatti S; Division of Oncology/Unit of Urology, URI; IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, Via Olgettina 60, 20131, Milan, Italy.
  • Knipper S; ORSI Academy, Ghent, Belgium.
  • Berquin C; Department of Urology, University of Modena and Reggio Emilia, Modena, Italy.
  • Develtere D; ORSI Academy, Ghent, Belgium.
  • Sinatti C; Department of Urology, University of Modena and Reggio Emilia, Modena, Italy.
  • Van Puyvelde H; Department of Urology, Onze-Lieve-Vrouwziekenhuis Hospital, Aalst, Belgium.
  • De Groote R; ORSI Academy, Ghent, Belgium.
  • De Naeyer G; ORSI Academy, Ghent, Belgium.
  • D'Hondt F; Department of Urology, Onze-Lieve-Vrouwziekenhuis Hospital, Aalst, Belgium.
  • Schatteman P; ORSI Academy, Ghent, Belgium.
  • Briganti A; ORSI Academy, Ghent, Belgium.
  • Montorsi F; Department of Urology, University of Modena and Reggio Emilia, Modena, Italy.
  • Mottrie A; Department of Urology, Onze-Lieve-Vrouwziekenhuis Hospital, Aalst, Belgium.
J Robot Surg ; 17(3): 1143-1150, 2023 Jun.
Article en En | MEDLINE | ID: mdl-36380261
Long-term oncologic data on patients undergoing robot-assisted radical cystectomy (RARC) for non-metastatic bladder cancer (BCa) are limited. The purpose of this study is to describe long-term oncologic outcomes of patients receiving robotic radical cystectomy at a high-volume European Institution. We analyzed data of 107 patients treated with RARC between 2003 and 2012 at a high-volume robotic center. Clinical, pathologic, and survival data at the latest follow-up were collected. Clinical recurrence (CR)-free survival, cancer-specific mortality (CSM)-free survival, and overall survival (OS) were plotted using Kaplan-Meier survival curves. Cox proportional hazard models investigated predictors of CR and CSM. Competing-risk regressions were utilized to depict cumulative incidences of death from BCa and death from other causes after RARC at long term. Pathologic nonorgan-confined BCa was found in 40% of patients, and 7 (7%) patients had positive soft tissue surgical margins. Median (interquartile range [IQR]) number of nodes removed was 11 (6, 14), and 26% of patients had pN + disease. Median (IQR) follow-up for survivors was 123 (117, 149) months. The 12-year CR-free, CSM-free and overall survival were 55% (95% confidence interval [CI] 44%, 65%), 62% (95% CI 50%, 72%), and 34% (95% CI 24%, 44%), respectively. Nodal involvement on final pathology was associated with poor prognosis on multivariable competing risk analysis. The cumulative incidence of non-cancer death exceeded that of death from BCa after approximately ten years after RARC. We provided relevant data on oncologic outcomes of RARC at a high-volume robotic center, with acceptable rates of clinical recurrence and cancer-specific survival at long-term. In patients treated with RARC, the cumulative incidence of death from causes other than BCa is non-negligible, and should be taken into consideration for post-operative follow-up.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Robótica / Procedimientos Quirúrgicos Robotizados Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Robot Surg Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Robótica / Procedimientos Quirúrgicos Robotizados Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Robot Surg Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido