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Lipin-1 stability and its adipogenesis functions are regulated in contrasting ways by AKT1 and LKB1.
Un Nisa, Misbah; Gillani, Syed Qaaifah; Nabi, Nusrat; Sarwar, Zarka; Reshi, Irfana; Bhat, Sameer Ahmed; Andrabi, Shaida.
Afiliación
  • Un Nisa M; Department of Biochemistry, University of Kashmir, Srinagar, 190006, India.
  • Gillani SQ; Department of Biochemistry, University of Kashmir, Srinagar, 190006, India.
  • Nabi N; Department of Biochemistry, University of Kashmir, Srinagar, 190006, India.
  • Sarwar Z; Department of Biochemistry, University of Kashmir, Srinagar, 190006, India.
  • Reshi I; Department of Biotechnology, University of Kashmir, Srinagar, 190006, India.
  • Bhat SA; Department of Biotechnology, University of Kashmir, Srinagar, 190006, India.
  • Andrabi S; Department of Biochemistry, University of Kashmir, Srinagar, 190006, India. shaida.andrabi@uok.edu.in.
J Cell Commun Signal ; 17(3): 689-704, 2023 Sep.
Article en En | MEDLINE | ID: mdl-36380131
Lipin-1 is a protein that plays a critical role in many cellular functions. At molecular level, it acts as a phosphatidic acid phosphohydrolase and a transcriptional coactivator. The functions of lipin-1 are largely dependent upon its subcellular localization, post-translational modifications like phosphorylation and acetylation, and also on its interaction with other proteins such as 14-3-3. However, the kinases and phosphatases that are responsible for these post translational modifications are not entirely known. Using bioinformatics and other biochemical approaches, we demonstrate lipin-1 as a novel target for AKT1 and LKB1. While AKT1 stabilizes lipin-1, LKB1 causes its degradation. Interestingly, our findings further show that lipin-1 enhances AKT1 activity as can be seen by increased phosphorylation of the substrates of AKT1. Taken together, our results suggest that lipin-1 plays an important role in the regulation of PI3K-AKT-mTOR pathway, which is dysregulated in majority of cancers. Therefore, understating the role of lipin-1 may provide new and important insights into the regulation and functions of the PI3K-mTOR pathway, which is one of the major targets for anti-cancer drug development strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Cell Commun Signal Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Cell Commun Signal Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos