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Auditory-limbic-cerebellum interactions and cognitive impairments in noise-induced hearing loss.
Xu, Xiao-Min; Feng, Yuan; Wang, Jian; Salvi, Richard; Yin, Xindao; Gao, Jun; Chen, Yu-Chen.
Afiliación
  • Xu XM; Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  • Feng Y; Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  • Wang J; School of Human Communication Disorders, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Salvi R; Center for Hearing and Deafness, University at Buffalo, Buffalo, New York, USA.
  • Yin X; Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  • Gao J; The Department of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University, Nanjing, China.
  • Chen YC; Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
CNS Neurosci Ther ; 29(3): 932-940, 2023 03.
Article en En | MEDLINE | ID: mdl-36377461
AIMS: This study aimed to explore the neural substrate of hearing loss-related central nervous system in rats and its correlation with cognition. METHODS: We identified the neural mechanism for these debilitating abnormalities by inducing a bilateral hearing loss animal model using intense broadband noise (122 dB of broadband noise for 2 h) and used the Morris water maze test to characterize the behavioral changes at 6 months post-noise exposure. Functional magnetic resonance imaging (fMRI) was conducted to clarify disrupted functional network using bilateral auditory cortex (ACx) as a seed. Structural diffusion tensor imaging (DTI) was applied to illustrate characteristics of fibers in ACx and hippocampus. Pearson correlation was computed behavioral tests and other features. RESULTS: A deficit in spatial learning/memory, body weight, and negative correlation between them was observed. Functional connectivity revealed weakened coupling within the ACx and inferior colliculus, lateral lemniscus, the primary motor cortex, the olfactory tubercle, hippocampus, and the paraflocculus lobe of the cerebellum. The fiber number and mean length of ACx and different hippocampal subregions were also damaged in hearing loss rats. CONCLUSION: A new model of auditory-limbic-cerebellum interactions accounting for noise-induced hearing loss and cognitive impairments is proposed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disfunción Cognitiva / Pérdida Auditiva Provocada por Ruido Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: CNS Neurosci Ther Asunto de la revista: NEUROLOGIA / TERAPEUTICA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disfunción Cognitiva / Pérdida Auditiva Provocada por Ruido Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: CNS Neurosci Ther Asunto de la revista: NEUROLOGIA / TERAPEUTICA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido