Your browser doesn't support javascript.
loading
LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug.
Cutano, Valentina; Ferreira Mendes, Jessica Marianne; Escudeiro-Lopes, Sara; Machado, Susana; Vinaixa Forner, Judith; Gonzales-Morena, Juan M; Prevorovsky, Martin; Zemlianski, Viacheslav; Feng, Yuxiong; Kralova Viziova, Petra; Hartmanova, Andrea; Malcekova, Beata; Jakoube, Pavel; Iyer, Sonia; Keckesova, Zuzana.
Afiliación
  • Cutano V; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.
  • Ferreira Mendes JM; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.
  • Escudeiro-Lopes S; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.
  • Machado S; Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic.
  • Vinaixa Forner J; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.
  • Gonzales-Morena JM; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.
  • Prevorovsky M; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.
  • Zemlianski V; Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic.
  • Feng Y; Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic.
  • Kralova Viziova P; Zhejiang Provincial Key Laboratory of Pancreatic Disease, First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.
  • Hartmanova A; The Czech Center for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic.
  • Malcekova B; The Czech Center for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic.
  • Jakoube P; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.
  • Iyer S; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.
  • Keckesova Z; Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic.
Life Sci Alliance ; 6(1)2023 01.
Article en En | MEDLINE | ID: mdl-36375842
Epithelial-mesenchymal transition (EMT) is a cellular mechanism used by cancer cells to acquire migratory and stemness properties. In this study, we show, through in vitro, in vivo, and 3D culture experiments, that the mitochondrial protein LACTB manifests tumor suppressor properties in ovarian cancer. We show that LACTB is significantly down-regulated in epithelial ovarian cancer cells and clinical tissues. Re-expression of LACTB negatively effects the growth of cancer cells but not of non-tumorigenic cells. Mechanistically, we show that LACTB leads to differentiation of ovarian cancer cells and loss of their stemness properties, which is achieved through the inhibition of the EMT program and the LACTB-dependent down-regulation of Snail2/Slug transcription factor. This study uncovers a novel role of LACTB in ovarian cancer and proposes new ways of counteracting the oncogenic EMT program in this model system.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Beta-Lactamasas / Transición Epitelial-Mesenquimal / Factores de Transcripción de la Familia Snail Límite: Female / Humans Idioma: En Revista: Life Sci Alliance Año: 2023 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Beta-Lactamasas / Transición Epitelial-Mesenquimal / Factores de Transcripción de la Familia Snail Límite: Female / Humans Idioma: En Revista: Life Sci Alliance Año: 2023 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Estados Unidos