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The combination of daptomycin with ß-lactam antibiotics is more effective than daptomycin alone for vancomycin-resistant Enterococcus faecium bloodstream infection.
Chuang, Yu-Chung; Wang, Jann-Tay; Yang, Jia-Ling; Lin, Chi-Ying; Huang, Sung-Hsi; Chen, Yee-Chun; Chang, Shan-Chwen.
Afiliación
  • Chuang YC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: yuchungchuang@ntu.edu.tw.
  • Wang JT; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
  • Yang JL; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
  • Lin CY; Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.
  • Huang SH; Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan.
  • Chen YC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
  • Chang SC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
J Infect Public Health ; 15(12): 1396-1402, 2022 Dec.
Article en En | MEDLINE | ID: mdl-36371936
BACKGROUND: The treatment options for vancomycin-resistant Enterococcus (VRE) are limited. A combination of daptomycin (DAP) and ß-lactam (BL) has been suggested; however clinical studies supporting this are lacking. METHODS: Patients with VR E. faecium bacteremia who received ≥ 8 mg/kg daptomycin for ≥ 72 h and initiated ≤ 5 days of culture collection between 2010 and 2021 were included. DAP+BL was defined as receiving BL for ≥ 24 h and within 24 h of DAP initiation. The primary endpoint was a composite clinical success (neither 14-day mortality, microbiological failure, nor change in the anti-VRE regimen). Outcomes were analyzed using multivariable logistic regression and augmented inverse probability weighting (AIPW). RESULTS: A total of 430 patients were enrolled (DAP, n = 45; DAP+BL, n = 385). Clinical success was achieved in 19 (42.2%) patients in the DAP group and 244 (63.4%) in the DAP+BL group [adjusted odds ratio, 3.19; 95% confidence interval (CI) 1.61-6.33; P = 0.001]. Marginal analysis showed that the efficacy of DAP+BL was particularly significant with DAP dose ≥ 9 mg/kg and DAP minimum inhibitory concentration (MIC) ≥ 2 mg/L. With the balance of AIPW, standardized mean clinical success rates for DAP and DAP+BL 37.3% and 63.5%, respectively. The difference between DAP+BL and DAP was of 26.2% in favor of DAP+BL (95% CI, 10.0-42.3%; P = 0.001). CONCLUSIONS: DAP+BL was associated with a significantly higher rate of compositive clinical success than DAP for treatment of VR E. faecium bacteremia. The study suggested BL in combination with high-dose DAP for VR E. faecium bacteremia treatment, especially when VRE showed a high DAP MIC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enterococcus faecium / Bacteriemia / Daptomicina / Enterococos Resistentes a la Vancomicina Límite: Humans Idioma: En Revista: J Infect Public Health Asunto de la revista: DOENCAS TRANSMISSIVEIS / SAUDE PUBLICA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enterococcus faecium / Bacteriemia / Daptomicina / Enterococos Resistentes a la Vancomicina Límite: Humans Idioma: En Revista: J Infect Public Health Asunto de la revista: DOENCAS TRANSMISSIVEIS / SAUDE PUBLICA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido