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miRNA-195-5p/PSAT1 feedback loop in human triple-negative breast cancer cells.
Wang, Huiling; Fang, Qian; You, Shuo; Wu, Yaqin; Zhang, Chaojie.
Afiliación
  • Wang H; Department of Breast and Thyroid Surgery, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), 410006, Changsha, Hunan, China.
  • Fang Q; Department of Breast and Thyroid Surgery, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), 410006, Changsha, Hunan, China.
  • You S; Department of Breast and Thyroid Surgery, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), 410006, Changsha, Hunan, China.
  • Wu Y; Department of Breast and Thyroid Surgery, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), 410006, Changsha, Hunan, China.
  • Zhang C; Department of Breast and Thyroid Surgery, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), 410006, Changsha, Hunan, China. chaojie1974@yeah.net.
Genes Genomics ; 45(1): 39-47, 2023 01.
Article en En | MEDLINE | ID: mdl-36371491
BACKGROUND: Substantial evidence suggests that non-coding RNAs, such as microRNAs (miRNAs), play a vital role in human cancer. Phosphoserine aminotransferase 1 (PSAT1) is a serine biosynthesis-related member of the aminotransferase family and is closely associated with worse prognosis in triple-negative breast cancer (TNBC). OBJECTIVE: The present study elucidated the molecular mechanisms underlying PSAT1 regulation by miRNAs in TNBC. METHODS: After collecting breast cancer and para-cancerous tissues, expression and functional testing of microRNA-195-5p (miR-195-5p) and PSAT1 were implemented both in vivo and in vitro. RESULTS: Abnormally low miR-195-5p expression was confirmed in TNBC tissues and cells. The specific targeting effect of miR-195-5p on PSAT1 was screened. Our observations revealed that biological tumor behavior was inhibited after miR-195-5p upregulation and this inhibition could be reversed by PSAT1 overexpression both in vivo and in vitro. CONCLUSION: Our study revealed the regulatory axis of miR-195-5p/PSAT1 in TNBC, suggesting a promising targeted therapy for clinical application.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Neoplasias de la Mama Triple Negativas Límite: Humans Idioma: En Revista: Genes Genomics Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Corea del Sur
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Neoplasias de la Mama Triple Negativas Límite: Humans Idioma: En Revista: Genes Genomics Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Corea del Sur