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Clinicopathological features and prognostic impact of dirty necrosis in metastatic lung cancers from the colon and rectum.
Konishi, Yasuhito; Taki, Tetsuro; Nakai, Tokiko; Kuroe, Takashi; Morisue, Ryo; Miyoshi, Tomohiro; Tane, Kenta; Samejima, Joji; Aokage, Keiju; Miyazaki, Saori; Sakamoto, Naoya; Sakashita, Shingo; Watanabe, Reiko; Kojima, Motohiro; Suzuki, Kenji; Tsuboi, Masahiro; Ishii, Genichiro.
Afiliación
  • Konishi Y; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Japan.
  • Taki T; Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
  • Nakai T; Departments of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan.
  • Kuroe T; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Japan.
  • Morisue R; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Japan.
  • Miyoshi T; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Japan.
  • Tane K; Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
  • Samejima J; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
  • Aokage K; Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
  • Miyazaki S; Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
  • Sakamoto N; Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
  • Sakashita S; Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
  • Watanabe R; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Japan.
  • Kojima M; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Japan.
  • Suzuki K; Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
  • Tsuboi M; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Japan.
  • Ishii G; Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Cancer Sci ; 114(5): 2169-2177, 2023 May.
Article en En | MEDLINE | ID: mdl-36369892
Dirty necrosis (DN) is a form of tumor necrosis (TN) with prominent neutrophil infiltration and cell detritus in the necrotic foci. This study aimed to characterize the clinicopathological features of DN in metastatic lung cancers of the colon and rectum (MLCRs). A total of 227 patients who underwent pulmonary metastasectomy and complete resection for MLCR were included in this study. TN was evaluated using digitally scanned resection specimens. These slides were immunostained for biomarkers of NETosis (citrullinated histone H3 [citH3] and myeloperoxidase [MPO]), and the area positive for citH3 and MPO was further quantified. TN was observed in 216 cases (95.2%), and 54 (25.0%) of these cases had DN. The presence of TN was not associated with a worse prognosis; however, patients with DN had a significantly shorter overall survival than those without DN (p < 0.01). Furthermore, the presence of DN was a poor prognostic factor in both the univariate and multivariate analyses. Immunohistochemical analysis revealed that the percentage of citH3-positive and MPO-positive areas in the DN-positive cases was significantly higher than that in the DN-negative cases (p < 0.01 and p < 0.01, respectively). In surgically resected MLCR, DN is the characteristic TN subtype associated with poor prognosis and neutrophil extracellular traps (NETs).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recto / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cancer Sci Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recto / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cancer Sci Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido