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Blood Center Testing Allows the Detection and Rapid Treatment of Acute and Recent HIV Infection.
van den Berg, Karin; Vermeulen, Marion; Bakkour, Sonia; Stone, Mars; Jacobs, Genevieve; Nyoni, Cynthia; Barker, Coreen; McClure, Christopher; Creel, Darryl; Grebe, Eduard; Roubinian, Nareg; Jentsch, Ute; Custer, Brian; Busch, Michael P; Murphy, Edward L.
Afiliación
  • van den Berg K; South African National Blood Service, Johannesburg 3610, South Africa.
  • Vermeulen M; South African National Blood Service, Johannesburg 3610, South Africa.
  • Bakkour S; Vitalant Research Institute, San Francisco, CA 94118, USA.
  • Stone M; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
  • Jacobs G; Vitalant Research Institute, San Francisco, CA 94118, USA.
  • Nyoni C; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
  • Barker C; South African National Blood Service, Johannesburg 3610, South Africa.
  • McClure C; South African National Blood Service, Johannesburg 3610, South Africa.
  • Creel D; Clinical HIV Research Unit, University of the Witwatersr, Johannesburg 2092, South Africa.
  • Grebe E; RTI International, Rockville, MD 20852, USA.
  • Roubinian N; RTI International, Rockville, MD 20852, USA.
  • Jentsch U; Vitalant Research Institute, San Francisco, CA 94118, USA.
  • Custer B; DSI-NRF Centre of Excellence in Epidemiological Modelling and Analysis (SACEMA), Stellenbosch University, Stellenbosch 7602, South Africa.
  • Busch MP; Vitalant Research Institute, San Francisco, CA 94118, USA.
  • Murphy EL; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
  • On Behalf Of The Recipient Epidemiology And Donor Evaluation Study Reds-Iii South Africa International Program; Kaiser Permanente Northern California, Oakland, CA 94612, USA.
Viruses ; 14(11)2022 10 23.
Article en En | MEDLINE | ID: mdl-36366424
Blood donations in South Africa are tested for HIV RNA using individual donation NAT (ID-NAT), allowing detection and rapid antiretroviral therapy (ART) of acute HIV infections. We enrolled a cohort of acute and recent HIV-infected blood donation candidates in South Africa in 2015-2018, measured HIV antibody, ID-NAT, and recency of infection <195 days (Sedia LAg) at enrollment and initiated early ART. A small cohort of HIV elite controllers was followed without treatment. HIV reservoir measurements included ultrasensitive plasma RNA, cell-associated HIV RNA, and total DNA. Enrollment of 18 Fiebig I-III and 45 Fiebig IV-VI HIV clade C subjects occurred a median of 18 days after index blood donation. ART was administered successfully and compliance with follow-up visits was excellent. There were only minimal differences in HIV reservoir between ART initiation in Fiebig stages I-III vs. IV-VI, but ART noncompliance increased HIV reservoir. In 11 untreated HIV elite controllers, HIV reservoir levels were similar to or higher than those seen in our early treated cohort. National blood services can identify acute HIV cohorts for subsequent HIV cure research studies. Among HIV clade C-infected donors, HIV reservoir differed little by Fiebig stage at treatment initiation, but was smaller than in chronically treated HIV and those with ART noncompliance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Viruses Año: 2022 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Viruses Año: 2022 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Suiza