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Nitrate in Maternal Drinking Water during Pregnancy and Measures of Male Fecundity in Adult Sons.
Clemmensen, Pernille Jul; Brix, Nis; Schullehner, Jörg; Gaml-Sørensen, Anne; Toft, Gunnar; Tøttenborg, Sandra Søgaard; Ebdrup, Ninna Hinchely; Hougaard, Karin Sørig; Hansen, Birgitte; Sigsgaard, Torben; Kolstad, Henrik Albert; Bonde, Jens Peter Ellekilde; Ramlau-Hansen, Cecilia Høst.
Afiliación
  • Clemmensen PJ; Department of Public Health, Aarhus University, 8000 Aarhus, Denmark.
  • Brix N; Department of Public Health, Aarhus University, 8000 Aarhus, Denmark.
  • Schullehner J; Department of Clinical Genetics, Aarhus University Hospital, 8200 Aarhus, Denmark.
  • Gaml-Sørensen A; Department of Public Health, Aarhus University, 8000 Aarhus, Denmark.
  • Toft G; Geological Survey of Denmark and Greenland, 8000 Aarhus, Denmark.
  • Tøttenborg SS; Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University, 8000 Aarhus, Denmark.
  • Ebdrup NH; Department of Public Health, Aarhus University, 8000 Aarhus, Denmark.
  • Hougaard KS; Steno Diabetes Center Aarhus, Aarhus University Hospital, 8200 Aarhus, Denmark.
  • Hansen B; Department of Occupational and Environmental Medicine, Copenhagen University Hospital-Bispebjerg and Frederiksberg Hospital, 2400 Copenhagen, Denmark.
  • Sigsgaard T; Department of Public Health, University of Copenhagen, 1014 Copenhagen, Denmark.
  • Kolstad HA; Fertility Clinic, The Regional Hospital in Horsens, 8700 Horsens, Denmark.
  • Bonde JPE; Department of Public Health, University of Copenhagen, 1014 Copenhagen, Denmark.
  • Ramlau-Hansen CH; National Research Centre for the Working Environment, 2100 Copenhagen, Denmark.
Int J Environ Res Public Health ; 19(21)2022 11 03.
Article en En | MEDLINE | ID: mdl-36361307
Animal studies indicate deleterious effects of nitrate exposure on fecundity, but effects in humans are unknown, both for the prenatal and postnatal periods. We aimed to investigate if exposure to nitrate in maternal drinking water during the sensitive period of fetal life is associated with measures of fecundity in the adult sons. In a sub-analysis, the potential effects of nitrate exposure in adulthood were investigated. This cohort included 985 young adult men enrolled in The Fetal Programming of Semen Quality Cohort (FEPOS). Semen characteristics, testes volume and reproductive hormones were analyzed in relation to nitrate concentration in maternal drinking water, using a negative binomial regression model. The nitrate concentration in drinking water was obtained from monitoring data from Danish waterworks that were linked with the mothers' residential address during pregnancy. The median nitrate concentration in maternal drinking water was 2 mg/L. At these low exposure levels, which are far below the World Health Organization's (WHO) guideline value of 50 mg/L, we did not find indications of harmful effects of nitrate on the investigated measures of male fecundity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Agua Potable Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Pregnancy Idioma: En Revista: Int J Environ Res Public Health Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Agua Potable Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Pregnancy Idioma: En Revista: Int J Environ Res Public Health Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Suiza