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HE4 Tissue Expression as A Putative Prognostic Marker in Low-Risk/Low-Grade Endometrioid Endometrial Cancer: A Review.
Mais, Valerio; Fais, Maria Luisa; Peiretti, Michele; Fanni, Daniela; Massa, Elena; Carboni, Giulia; Fais, Giuseppina; Deo, Giuseppe; Angioni, Stefano.
Afiliación
  • Mais V; Department of Surgical Sciences, University of Cagliari Medical School, 09042 Cagliari, Italy.
  • Fais ML; Department of Surgical Sciences, University of Cagliari Medical School, 09042 Cagliari, Italy.
  • Peiretti M; Division of Gynecology and Obstetrics (AOU di Cagliari), Department of Surgical Sciences, University of Cagliari, 09042 Cagliari, Italy.
  • Fanni D; Division of Pathology (AOU di Cagliari), Department of Medical Sciences and Public Health, University of Cagliari, 09042 Cagliari, Italy.
  • Massa E; Division of Oncology (AOU di Cagliari), Department of Medical Sciences and Public Health, University of Cagliari, 09042 Cagliari, Italy.
  • Carboni G; Department of Surgical Sciences, University of Cagliari Medical School, 09042 Cagliari, Italy.
  • Fais G; Department of Surgical Sciences, University of Cagliari Medical School, 09042 Cagliari, Italy.
  • Deo G; Department of Surgical Sciences, University of Cagliari Medical School, 09042 Cagliari, Italy.
  • Angioni S; Department of Surgical Sciences, University of Cagliari Medical School, 09042 Cagliari, Italy.
Curr Oncol ; 29(11): 8540-8555, 2022 11 10.
Article en En | MEDLINE | ID: mdl-36354733
Low-grade stage I endometrioid endometrial carcinomas should have an excellent prognosis, but a small subset of these cancers can relapse. The search for putative immunohistochemical prognostic markers for relapse in low-risk/low-grade endometrioid endometrial cancers remains open. Among the candidate molecules that may implicate the roles of immunohistochemical risk markers, we focused our attention on human epididymis protein 4 (HE4) after a review of the literature. Few authors have devoted themselves to this topic, and none have found a correlation between the tissue expression of HE4 and the molecular classification of endometrial cancer. Five different variants of HE4 mRNA and multiple protein isoforms of HE4 were identified many years ago, but current HE4 assays only measure the total HE4 expression and do not distinguish the different proteins encoded by different mRNA variants. It is important to have an approach to distinguish specific variants in the future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Neoplasias Endometriales Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Curr Oncol Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Neoplasias Endometriales Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Curr Oncol Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza