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Factors associated with the periodicity of Loa loa microfilaremia in the Republic of the Congo.
Campillo, Jérémy T; Louya, Frédéric; Bikita, Paul; Missamou, François; Pion, Sébastien D S; Boussinesq, Michel; Chesnais, Cédric B.
Afiliación
  • Campillo JT; Institut de Recherche Pour le Développement (IRD), TransVIHMI, Université de Montpellier, INSERM Unité 1175, Montpellier, France. jeremy.campillo@ird.fr.
  • Louya F; Programme National de Lutte Contre L'Onchocercose, Direction de l'Épidémiologie et de la Lutte Contre la Maladie, Ministère de la Santé et de la Population, Brazzaville, Republic of Congo.
  • Bikita P; Programme National de Lutte Contre L'Onchocercose, Direction de l'Épidémiologie et de la Lutte Contre la Maladie, Ministère de la Santé et de la Population, Brazzaville, Republic of Congo.
  • Missamou F; Programme National de Lutte Contre L'Onchocercose, Direction de l'Épidémiologie et de la Lutte Contre la Maladie, Ministère de la Santé et de la Population, Brazzaville, Republic of Congo.
  • Pion SDS; Institut de Recherche Pour le Développement (IRD), TransVIHMI, Université de Montpellier, INSERM Unité 1175, Montpellier, France.
  • Boussinesq M; Institut de Recherche Pour le Développement (IRD), TransVIHMI, Université de Montpellier, INSERM Unité 1175, Montpellier, France.
  • Chesnais CB; Institut de Recherche Pour le Développement (IRD), TransVIHMI, Université de Montpellier, INSERM Unité 1175, Montpellier, France.
Parasit Vectors ; 15(1): 417, 2022 Nov 09.
Article en En | MEDLINE | ID: mdl-36352480
BACKGROUND: Loa loa microfilariae circulate in the peripheral blood of human hosts following a diurnal periodicity, with maximal microfilaremia levels generally observed between 10:00 am and 3:00 pm. Few studies have assessed factors potentially associated with this periodicity. METHODS: Microfilaremia data were collected repeatedly between 9:00 am and 8:00 pm from 13 individuals in the Republic of the Congo. Using local polynomial regression (LOESS), we determined the best models representing the dynamics of microfilaremia over this period. In a second step, using cosinor models, we evaluated the influence of sex, age, and body temperature on the periodicity of L. loa microfilaremia in blood. RESULTS: All subjects reached their maximum microfilaremia between 10:00 am and 4:00 pm. Individual microfilaremia showed different patterns between individuals, and some clearly showed multiple peaks within a day. LOESS provided a good fit to the observed data. Without adjustment, the maximum microfilarial density was reached around 11:00 am. Adjustment revealed three distinct modes of microfilaremia, occurring around 10:00 am, 1:00 pm, and 4:00 pm. Cosinor models also provided good fit to our data. After adjustment on body temperature, the L. loa microfilaremia fluctuation amplitude decreased significantly from 1684.8 to 310.6 microfilariae(mf)/ml and the predicted peak was estimated at 12:02 pm. CONCLUSIONS: We characterized the periodicity of L. loa microfilaremia mathematically with two different approaches: cosinor models and LOESS regression. Both models suggest that body temperature plays a role in the variation in microfilaremia within a day. Further studies are needed to identify individual co-factors affecting microfilaremia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Loiasis / Loa Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans País/Región como asunto: Africa Idioma: En Revista: Parasit Vectors Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Loiasis / Loa Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans País/Región como asunto: Africa Idioma: En Revista: Parasit Vectors Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido