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An inhibitory effect of schisandrone on α-hemolysin expression to combat methicillin-resistant staphylococcus aureus infections.
Qi, Yingxin; Hou, Juan; Zhao, Yicheng; Song, Wu; Wang, Li; Chen, Huan; Chen, Guang.
Afiliación
  • Qi Y; College of Life Science, Key Laboratory of Straw Biology and Utilization of the Ministry of Education Jilin Agricultural University, Changchun, China.
  • Hou J; School of Biological and Food Engineering, Jilin Engineering Normal University, Changchun, China.
  • Zhao Y; College of Clinical Medicine, Changchun University of Chinese Medicine, Changchun, China.
  • Song W; College of Clinical Medicine, Changchun University of Chinese Medicine, Changchun, China.
  • Wang L; Center for Pathogen Biology and Infectious Diseases, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China.
  • Chen H; College of Clinical Medicine, Changchun University of Chinese Medicine, Changchun, China.
  • Chen G; College of Clinical Medicine, Changchun University of Chinese Medicine, Changchun, China.
World J Microbiol Biotechnol ; 39(1): 3, 2022 Nov 08.
Article en En | MEDLINE | ID: mdl-36344903
Due to increasing antibiotic resistance, targeting bacterial virulence factors is now gaining further interest as an alternative strategy to develop novel classes of anti-infective agents. The critical role of α-hemolysin (Hla), an indispensable virulence determinant, in the pathogenicity of Staphylococcus aureus renders this virulence factor an appealing target for effective therapeutic applications. Herein, we identified a natural compound schisandraone, as an effective Hla inhibitor, which could inhibit Hla production and thus hemolytic activity in a dose-dependent manner without affecting the growth of S. aureus. We also found that the addition of schisandrone could down-regulate the transcriptional levels of the hla, agrA and RNAIII and significantly alleviated Hla-mediated injury of A549 cells co-cultured with S. aureus. In vivo studies further suggested that schisandrone combined with antibiotic ceftiofur exhibited a significant therapeutic effect on S. aureus infection. These findings revealed the role of schisandrone in inhibiting the activity of Hla and we believe that it is a promising anti-virulence candidate to combat MRSA pneumonia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Estafilocócica / Infecciones Estafilocócicas / Toxinas Bacterianas / Staphylococcus aureus Resistente a Meticilina Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: World J Microbiol Biotechnol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Estafilocócica / Infecciones Estafilocócicas / Toxinas Bacterianas / Staphylococcus aureus Resistente a Meticilina Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: World J Microbiol Biotechnol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania