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Soluble Corin Predicts the Risk of Cardiovascular Disease: A 10-Year Follow-Up Study.
Chen, Linan; Zhang, Qiu; Zhang, Min; Yu, Jia; Ren, Liyun; Li, Jing; Ma, Shengqi; He, Yan; Hu, Weidong; Peng, Hao.
Afiliación
  • Chen L; Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
  • Zhang Q; Department of Chronic Disease, Gusu Center for Disease Control and Prevention, Suzhou, China.
  • Zhang M; Central Office, Suzhou National New and Hi-tech Industrial Development Zone Center for Disease Control and Prevention, Suzhou, China.
  • Yu J; Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
  • Ren L; Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
  • Li J; Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
  • Ma S; Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
  • He Y; Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
  • Hu W; Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou, China.
  • Peng H; Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
JACC Asia ; 2(4): 490-501, 2022 Aug.
Article en En | MEDLINE | ID: mdl-36339355
Background: As a key enzyme of the natriuretic peptides system, corin may participate in the development of cardiovascular disease (CVD). Its level in circulation predicted CVD recurrence in patients with myocardial infarction and heart failure, but no study examined this prediction in general populations. Objectives: This study sought to examine the prospective association between corin and CVD in a community-based population of Chinese adults. Methods: The Gusu cohort included 2,498 participants (mean age 53 years, 39% men) who were free of CVD at baseline. Serum corin was measured by enzyme-linked immunosorbent assay kits at baseline and CVD events were followed every 2 years for all participants. A competing-risks survival regression model was used to examine the association between serum corin and CVD. Results: During 10 years of follow-up, 210 participants developed CVD including 88 stroke events. A higher serum corin (after log-transformation) at baseline was significantly associated with an increased risk of CVD (HR: 1.88; P = 0.019) and stroke (HR: 3.19; P = 0.014). Analysis using categorical serum corin (in quartiles) showed that participants in the highest quartile had a 62% and 179% increased risk for CVD (HR: 1.62; P = 0.024) and stroke (HR: 2.79; P = 0.004), respectively, compared with those in the lowest quartile. We did not find a significant association between serum corin and coronary heart disease. Conclusions: A higher serum corin at baseline predicted a higher risk of CVD events and stroke, but not coronary heart disease, in Chinese adults, independent of conventional risk factors. Serum corin may be a predictor for stroke but the underlying mechanism needs further investigation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: JACC Asia Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: JACC Asia Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos