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An NTRK-1-associated soft tissue tumor showing distinctive nodules with peripheral accentuation of cellularity.
Czaja, Rebecca; Layng, Kayla Viets; Barrett, Alex; Hooper, Perry; Alomari, Ahmed; Warren, Simon.
Afiliación
  • Czaja R; Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Layng KV; Tempus Labs Inc, Chicago, Illinois, USA.
  • Barrett A; Tempus Labs Inc, Chicago, Illinois, USA.
  • Hooper P; Department of Dermatology, Indiana University, Indianapolis, Indiana, USA.
  • Alomari A; Department of Pathology and Dermatology, Indiana University, Indianapolis, Indiana, USA.
  • Warren S; Department of Pathology and Dermatology, Indiana University, Indianapolis, Indiana, USA.
J Cutan Pathol ; 50(4): 343-348, 2023 Apr.
Article en En | MEDLINE | ID: mdl-36335562
Lipofibromatosis-like neural tumor is a recently described entity defined by a low-cellularity spindle cell infiltrate in the subcutaneous fat with admixed inflammatory cells. This tumor is histopathologically similar to lipofibromatosis, but unlike lipofibromatosis shows reactivity for S100 and has an NTRK-1 kinase fusion. These lesions are locally aggressive but appear to have a negligible metastatic potential. Subsequently, a more cellular variant has been described with generally low mitotic rate. This variant also displays S100 reactivity and kinase fusions (typically involving NTRK-1), but it has a low risk of metastasis. In this report, we describe a case that aligns with the more cellular variant of NTRK-1 kinase fusion tumors on histopathologic, immunohistochemical, and molecular grounds, but in addition has distinctive nodules with peripheral accentuation of cellularity, reminiscent of those present in epithelioid malignant peripheral nerve sheath tumors. This latter feature is previously undescribed in NTRK kinase fusion soft tissue tumors and offers further support for the presumed neural differentiation of this neoplasm.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Neoplasias de los Tejidos Blandos / Neoplasias de la Mama Tipo de estudio: Risk_factors_studies Límite: Female / Humans Idioma: En Revista: J Cutan Pathol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Neoplasias de los Tejidos Blandos / Neoplasias de la Mama Tipo de estudio: Risk_factors_studies Límite: Female / Humans Idioma: En Revista: J Cutan Pathol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos