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Impact of late gadolinium enhancement extent, location, and pattern on ventricular tachycardia and major adverse cardiac events in patients with ischemic vs. non-ischemic cardiomyopathy.
Tat, Emily; Ball, Caroline; Camren, Gerald P; Wroblewski, Igor; Dajani, Khaled A; Goldberg, Ari; Kinno, Menhel; Sanagala, Thriveni; Syed, Mushabbar A; Wilber, David J; Rabbat, Mark.
Afiliación
  • Tat E; Department of Internal Medicine, Columbia University Medical Center, New York, NY, United States.
  • Ball C; Division of Cardiology, Loyola University Medical Center, Maywood, IL, United States.
  • Camren GP; Department of Radiology, Loyola University Medical Center, Maywood, IL, United States.
  • Wroblewski I; Division of Cardiology, Loyola University Medical Center, Maywood, IL, United States.
  • Dajani KA; Division of Cardiology, Loyola University Medical Center, Maywood, IL, United States.
  • Goldberg A; Department of Radiology, Loyola University Medical Center, Maywood, IL, United States.
  • Kinno M; Division of Cardiology, Loyola University Medical Center, Maywood, IL, United States.
  • Sanagala T; Division of Cardiology, Loyola University Medical Center, Maywood, IL, United States.
  • Syed MA; Division of Cardiology, Loyola University Medical Center, Maywood, IL, United States.
  • Wilber DJ; Division of Cardiology, Loyola University Medical Center, Maywood, IL, United States.
  • Rabbat M; Division of Cardiology, Loyola University Medical Center, Maywood, IL, United States.
Front Cardiovasc Med ; 9: 1026215, 2022.
Article en En | MEDLINE | ID: mdl-36330014
Background: Left ventricular late gadolinium enhancement (LGE) by cardiac magnetic resonance (CMR) has been associated with increased risk for life-threatening ventricular tachyarrhythmias. The differences in association between LGE characteristics and prognosis in patients with ischemic (ICM) vs. non-ischemic (NICM) cardiomyopathy is incompletely understood. Methods: A total of 168 consecutive patients who underwent CMR imaging with either ICM or NICM were included in our study. LGE extent, location and pattern were examined for association to the primary endpoint of ventricular tachycardia (VT) and secondary endpoint of major adverse cardiac events (MACE). Results: Of 68 (41%) patients with ICM and 97 (59%) patients with NICM, median LGE mass was 15% (IQR 9-28) for the ICM group and 10% (IQR 6-15) for the NICM group. On multivariate analysis for both groups, LGE characteristics were prognostic while LVEF was not. In patients with ICM, septal and apical segment LGE, and involvement of multiple walls predicted both endpoints on multivariate analysis. LGE extent (≥median) and inferior wall LGE independently predicted the primary endpoint. In patients with NICM, anterior, inferior and apical segment LGE, and involvement of multiple walls predicted both endpoints on multivariate analysis. LGE extent (≥median, number of LGE segments, LGE stratified per 5% increase) and midwall LGE were independent predictors of the primary endpoint. Conclusions: Although LGE was an independent predictor of prognosis in both groups, LGE extent, location, and pattern characteristics were more powerful correlates to worse outcomes in patients with NICM than ICM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Cardiovasc Med Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Cardiovasc Med Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza