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Significance and Potential Role of Eosinophils in Non-Cystic Fibrosis Bronchiectasis.
Guan, Wei-Jie; Oscullo, Grace; He, Meng-Zhang; Xu, Dan-Yuan; Gómez-Olivas, Jose Daniel; Martinez-Garcia, Miguel Angel.
Afiliación
  • Guan WJ; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China; Department of Thoracic Surgery, Guangzhou Institute of Respirato
  • Oscullo G; Department of Pneumology, Hospital Universitario y Politécnico La Fe de Valencia, Valencia, Spain.
  • He MZ; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Xu DY; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Gómez-Olivas JD; Department of Pneumology, Hospital Universitario y Politécnico La Fe de Valencia, Valencia, Spain.
  • Martinez-Garcia MA; Department of Pneumology, Hospital Universitario y Politécnico La Fe de Valencia, Valencia, Spain; CIBERes, Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. Electronic address: mianmartinezgarcia@gmail.com.
J Allergy Clin Immunol Pract ; 11(4): 1089-1099, 2023 04.
Article en En | MEDLINE | ID: mdl-36323380
Bronchiectasis is a complex and heterogeneous disease with a myriad of pulmonary and extrapulmonary etiologies. Bronchiectasis has a predominantly neutrophilic inflammatory profile. However, eosinophilic inflammation has also been documented in both the airways and the systemic circulation. Various diseases (eg, asthma, allergic bronchopulmonary aspergillosis, chronic rhinosinusitis with nasal polyps) characterized by heightened type 2 airway inflammatory responses, including blood or sputum eosinophilia, may coexist with bronchiectasis. Apart from those eosinophilic etiologies or comorbidities related to bronchiectasis, around 20% of patients with bronchiectasis have peripheral eosinophilia (at least 3% or 300 eosinophils/µL) with no identified concomitant disease (also termed "eosinophilic bronchiectasis"), whose roles have not been fully understood. The two key points regarding these observations are that eosinophils confer both bactericidal and antiviral properties against common pathogenic microorganisms that are usually detected in bronchiectasis, and that eosinophilic bronchiectasis has been associated with better therapeutic response to inhaled corticosteroids and other anti-TH2 profile treatments. In this review, we summarize the most significant evidence regarding the role of eosinophils in patients with bronchiectasis, including the association of bronchiectasis with eosinophilic diseases (as etiologies or comorbidities), and existing data on eosinophilic bronchiectasis not related to eosinophilic disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bronquiectasia / Eosinofilia Límite: Humans Idioma: En Revista: J Allergy Clin Immunol Pract Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bronquiectasia / Eosinofilia Límite: Humans Idioma: En Revista: J Allergy Clin Immunol Pract Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos