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An Advanced Thermal Decomposition Method to Produce Magnetic Nanoparticles with Ultrahigh Heating Efficiency for Systemic Magnetic Hyperthermia.
Demessie, Ananiya A; Park, Youngrong; Singh, Prem; Moses, Abraham S; Korzun, Tetiana; Sabei, Fahad Y; Albarqi, Hassan A; Campos, Leonardo; Wyatt, Cory R; Farsad, Khashayar; Dhagat, Pallavi; Sun, Conroy; Taratula, Olena R; Taratula, Oleh.
Afiliación
  • Demessie AA; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR, 97201, USA.
  • Park Y; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR, 97201, USA.
  • Singh P; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR, 97201, USA.
  • Moses AS; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR, 97201, USA.
  • Korzun T; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR, 97201, USA.
  • Sabei FY; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR, 97201, USA.
  • Albarqi HA; Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, 88723, Kingdom of Saudi Arabia.
  • Campos L; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR, 97201, USA.
  • Wyatt CR; Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, 55461, Kingdom of Saudi Arabia.
  • Farsad K; Dotter Interventional Institute, Department of Interventional Radiology, Oregon Health & Science University, Portland, OR, 97239, USA.
  • Dhagat P; Department of Diagnostic Radiology, Oregon Health & Sciences University, Portland, OR, 97239, USA.
  • Sun C; Advanced Imaging Research Center, Oregon Health & Sciences University, Portland, OR, 97239, USA.
  • Taratula OR; Dotter Interventional Institute, Department of Interventional Radiology, Oregon Health & Science University, Portland, OR, 97239, USA.
  • Taratula O; School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR, 97331, USA.
Small Methods ; 6(12): e2200916, 2022 12.
Article en En | MEDLINE | ID: mdl-36319445
Due to the limited heating efficiency of available magnetic nanoparticles, it is difficult to achieve therapeutic temperatures above 44 °C in relatively inaccessible tumors during magnetic hyperthermia following systemic administration of nanoparticles at clinical dosage (≤10 mg kg-1 ). To address this, a method for the preparation of magnetic nanoparticles with ultrahigh heating capacity in the presence of an alternating magnetic field (AMF) is presented. The low nitrogen flow rate of 10 mL min-1 during the thermal decomposition reaction results in cobalt-doped nanoparticles with a magnetite (Fe3 O4 ) core and a maghemite (γ-Fe2 O3 ) shell that exhibit the highest intrinsic loss power reported to date of 47.5 nH m2 kg-1 . The heating efficiency of these nanoparticles correlates positively with increasing shell thickness, which can be controlled by the flow rate of nitrogen. Intravenous injection of nanoparticles at a low dose of 4 mg kg-1 elevates intratumoral temperatures to 50 °C in mice-bearing subcutaneous and metastatic cancer grafts during exposure to AMF. This approach can also be applied to the synthesis of other metal-doped nanoparticles with core-shell structures. Consequently, this method can potentially be used for the development of novel nanoparticles with high heating performance, further advancing systemic magnetic hyperthermia for cancer treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas de Magnetita / Hipertermia Inducida / Neoplasias Límite: Animals Idioma: En Revista: Small Methods Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas de Magnetita / Hipertermia Inducida / Neoplasias Límite: Animals Idioma: En Revista: Small Methods Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania