Your browser doesn't support javascript.
loading
Increased retinal drusen in IgA glomerulonephritis are further evidence for complement activation in disease pathogenesis.
Harraka, P; Wightman, Tony; Akom, Sarah; Sandhu, Kieran; Colville, Deb; Catran, Andrew; Langsford, David; Pianta, Timothy; Barit, David; Ierino, Frank; Skene, Alison; Mack, Heather; Savige, Judy.
Afiliación
  • Harraka P; Department of Medicine, Northern Health, The University of Melbourne, Parkville, VIC, 3050, Australia.
  • Wightman T; Department of Medicine, Melbourne Health, The University of Melbourne, Parkville, VIC, 3050, Australia.
  • Akom S; Department of Medicine, Northern Health, The University of Melbourne, Parkville, VIC, 3050, Australia.
  • Sandhu K; Department of Medicine, Melbourne Health, The University of Melbourne, Parkville, VIC, 3050, Australia.
  • Colville D; Department of Medicine, Northern Health, The University of Melbourne, Parkville, VIC, 3050, Australia.
  • Catran A; Department of Medicine, Melbourne Health, The University of Melbourne, Parkville, VIC, 3050, Australia.
  • Langsford D; Department of Medicine, Northern Health, The University of Melbourne, Parkville, VIC, 3050, Australia.
  • Pianta T; Department of Medicine, Melbourne Health, The University of Melbourne, Parkville, VIC, 3050, Australia.
  • Barit D; Department of Medicine, Northern Health, The University of Melbourne, Parkville, VIC, 3050, Australia.
  • Ierino F; Department of Medicine, Melbourne Health, The University of Melbourne, Parkville, VIC, 3050, Australia.
  • Skene A; Department of Medicine, Northern Health, The University of Melbourne, Parkville, VIC, 3050, Australia.
  • Mack H; Department of Medicine, Melbourne Health, The University of Melbourne, Parkville, VIC, 3050, Australia.
  • Savige J; Department of Medicine, Northern Health, The University of Melbourne, Parkville, VIC, 3050, Australia.
Sci Rep ; 12(1): 18301, 2022 10 31.
Article en En | MEDLINE | ID: mdl-36316518
Drusen are retinal deposits comprising cell debris, immune material and complement that are characteristic of macular degeneration but also found in glomerulonephritis. This was a pilot cross-sectional study to determine how often drusen occurred in IgA glomerulonephritis and their clinical significance. Study participants underwent non-mydriatic retinal photography, and their deidentified retinal images were examined for drusen by two trained graders, who compared central drusen counts, counts ≥ 10 and drusen size with those of matched controls. The cohort comprised 122 individuals with IgA glomerulonephritis including 89 males (73%), 49 individuals (40%) of East Asian or Southern European ancestry, with an overall median age of 54 years (34-64), and median disease duration of 9 years (4-17). Thirty-nine (33%) had an eGFR < 60 ml/min/1.73 m2 and 72 had previously reached kidney failure (61%). Overall mean drusen counts were higher in IgA glomerulonephritis (9 ± 27) than controls (2 ± 7, p < 0.001). Central counts ≥ 10 were also more common (OR = 3.31 (1.42-7.73, p = 0.006), and were associated with longer disease duration (p = 0.03) but not kidney failure (p = 0.31). Larger drusen were associated with more mesangial IgA staining (p = 0.004). Increased drusen counts were also present in IgA glomerulonephritis secondary to Crohn's disease but not with Henoch-Schonlein purpura. The finding of retinal drusen in IgA glomerulonephritis is consistent with complement activation and represents a model for better understanding glomerular immune deposition and a supporting argument for treatment with anti-complement therapies.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasculitis por IgA / Drusas Retinianas / Glomerulonefritis / Glomerulonefritis por IGA Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasculitis por IgA / Drusas Retinianas / Glomerulonefritis / Glomerulonefritis por IGA Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido