A Histologic Timeline of a Delayed Hypersensitivity Reaction after the COVID-19 Pfizer Booster.
Skinmed
; 20(5): 387-389, 2022.
Article
en En
| MEDLINE
| ID: mdl-36314709
A 54-year-old man presented with worsening bilateral rashes on legs and arms 7 days after receiving his BNT162b2 mRNA COVID-19 (Pfizer) vaccine booster. He developed burning on his palms about 5 days after receiving the booster. On day 6, he observed significant edema on his fingers and palms in addition to thin erythematous papules on his forearms. On day 7, he developed edema on his bilateral dorsal feet, and thin erythematous plaques on his shins. He stated that the rashes were pruritic. He had no rashes following the first two doses of the Pfizer vaccine. He denied having any history of skin disease, autoimmune disease, or allergies. Physical examination revealed multiple thin erythematous papules coalescing into thin plaques on his flexor forearms, and thin erythematous plaques on his dorsal feet (Figure 1). Three 4-mm punch biopsies were performed on his left flexor forearm. The biopsies were carried out at papules present for different lengths of time. Papules at biopsy sites "A," "B," and "C" were present for approximately 24-36 hours, 12-18 hours, and 3-6 hours, respectively (Figure 1).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
COVID-19
/
Hipersensibilidad Tardía
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Skinmed
Asunto de la revista:
DERMATOLOGIA
Año:
2022
Tipo del documento:
Article
Pais de publicación:
Estados Unidos