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Impaired Morris water task retention following T21 light dark cycle exposure is not due to reduced hippocampal c-FOS expression.
Deibel, Scott H; Higdon, S; Cassell, T T S; House-Denine, M L; Giberson, E; Webb, I C; Thorpe, C M.
Afiliación
  • Deibel SH; Department of Psychology, University of New Brunswick, Fredericton, NB, Canada.
  • Higdon S; Department of Psychology, Memorial University of Newfoundland, St. John's, NL, Canada.
  • Cassell TTS; Department of Psychology, Memorial University of Newfoundland, St. John's, NL, Canada.
  • House-Denine ML; Department of Psychology, Memorial University of Newfoundland, St. John's, NL, Canada.
  • Giberson E; Department of Psychology, University of New Brunswick, Fredericton, NB, Canada.
  • Webb IC; Department of Psychology, Memorial University of Newfoundland, St. John's, NL, Canada.
  • Thorpe CM; Department of Psychology, Memorial University of Newfoundland, St. John's, NL, Canada.
Front Behav Neurosci ; 16: 1025388, 2022.
Article en En | MEDLINE | ID: mdl-36311860
Circadian rhythms influence virtually all aspects of physiology and behavior. This is problematic when circadian rhythms no longer reliably predict time. Circadian rhythm disruption can impair memory, yet we don't know how this fully works at the systems and molecular level. When trying to determine the root of a memory impairment, assessing neuronal activation with c-FOS is useful. This has yet to be assessed in the hippocampi of circadian rhythm disrupted rats in a hippocampal gold standard task. Rats were trained on the Morris water task (MWT), then received 6 days of a 21-h day (T21), 13 days of a normal light dark cycle, probe trial, and tissue extraction an hour later. Despite having impaired memory in the probe trial, compared to controls there were no differences in c-FOS expression in hippocampal sub regions: CA1; CA3; Dentate gyrus. These data confirm others in hamsters demonstrating that arrhythmicity which produces an impairment in spontaneous alternation does not affect c-FOS in the dentate gyrus. The current study indicates that the memory impairment induced by a lighting manipulation is likely not due to attenuated neuronal activation. Determining how the master clock in the brain communicates with the hippocampus is needed to untangle the relationship between circadian rhythms and memory.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Behav Neurosci Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Behav Neurosci Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza