Implementing computational methods in tandem with synonymous gene recoding for therapeutic development.

Lin, Brian C; Kaissarian, Nayiri M; Kimchi-Sarfaty, Chava

Lin, Brian C; Kaissarian, Nayiri M; Kimchi-Sarfaty, Chava.

Afiliación

Lin BC; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation & Research, US FDA, Silver Spring, MD, USA.
Kaissarian NM; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation & Research, US FDA, Silver Spring, MD, USA.
Kimchi-Sarfaty C; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation & Research, US FDA, Silver Spring, MD, USA. Electronic address: Chava.Kimchi-Sarfaty@fda.hhs.gov.

Trends Pharmacol Sci ; 44(2): 73-84, 2023 Feb.

Article en En | MEDLINE | ID: mdl-36307252

Asunto(s)

Codón; Diseño de Fármacos; Terapéutica; Humanos; Codón/genética; Aprendizaje Automático

Palabras clave

codon optimization; codon usage; drug design; machine learning; synonymous variants; therapeutics

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapéutica / Codón / Diseño de Fármacos Límite: Humans Idioma: En Revista: Trends Pharmacol Sci Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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