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Cardiac sympathetic denervation could be associated with dysphagia in Parkinson's disease.
Youn, Jinyoung; Umemoto, George; Oh, Eungseok; Park, Jinse; Jang, Wooyoung; Oh, Yoon-Sang; Kim, Hee-Tae; Cho, Jin Whan; Fujioka, Shinsuke; Tsuboi, Yoshio.
Afiliación
  • Youn J; Department of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea.
  • Umemoto G; Swallowing Disorders Center, Fukuoka University Hospital, Fukuoka, Japan.
  • Oh E; Department of Neurology, Chungnam National University College of Medicine, Chungnam National University Hospital, Daejeon, South Korea.
  • Park J; Department of Neurology, Inje University, Haeundae Paik Hospital, Busan, South Korea.
  • Jang W; Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, South Korea.
  • Oh YS; Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Kim HT; Department of Neurology, Hanyang University College of Medicine, Seoul, South Korea.
  • Cho JW; Department of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea.
  • Fujioka S; Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
  • Tsuboi Y; Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Front Neurol ; 13: 1010006, 2022.
Article en En | MEDLINE | ID: mdl-36303556
Background: Dysphagia is an important non-motor symptom that is closely associated with quality of living and mortality in Parkinson's disease (PD). However, the pathophysiology of dysphagia in PD remains inconclusive. We tried to confirm whether the occurrence of dysphagia could be related to sympathetic degeneration using cardiac 123I-metaiodobenzylguanidine (MIBG) scintigraphy. Methods: We prospectively recruited 27 PD patients and classified them into two groups (PD with dysphagia vs. PD without dysphagia) by Swallowing Disturbance Questionnaire (SDQ) score and compared the clinical characteristics, videofluoroscopic swallowing study (VFSS) findings and parameters from cardiac MIBG scintigraphy. Results: The mean early and late H/M ratios were significantly lower in the PD with dysphagia group than those in the PD without dysphagia group (1.39 ± 0.21 vs. 1.86 ± 0.21, p < 0.01; 1.26 ± 0.18 vs. 1.82 ± 0.29, p < 0.01). In the correlation analysis, both the early and late H/M ratios were negatively correlated with the SDQ score and total VDS score (r = -0.65, p < 0.01; r = -0.53, p < 0.01; r = -0.65, p < 0.01, r = -0.58, p < 0.01). Conclusion: We confirmed that cardiac sympathetic denervation might be associated with the presence and severity of dysphagia. This finding indicates that dysphagia in PD could be associated with a nondopaminergic mechanism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Front Neurol Año: 2022 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Front Neurol Año: 2022 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Suiza