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Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women.
Peduzzi, Giulia; Archibugi, Livia; Katzke, Verena; Gentiluomo, Manuel; Capurso, Gabriele; Milanetto, Anna Caterina; Gazouli, Maria; Goetz, Mara; Brenner, Hermann; Vermeulen, Roel C H; Talar-Wojnarowska, Renata; Vanella, Giuseppe; Tavano, Francesca; Lucchesi, Maurizio; Mohelnikova-Duchonova, Beatrice; Chen, Xuechen; Kiudelis, Vytautas; Hegyi, Péter; Oliverius, Martin; Stocker, Hannah; Stornello, Caterina; Vodickova, Ludmila; Soucek, Pavel; Neoptolemos, John P; Testoni, Sabrina Gloria Giulia; Morelli, Luca; Lawlor, Rita T; Basso, Daniela; Izbicki, Jakob R; Ermini, Stefano; Kupcinskas, Juozas; Pezzilli, Raffaele; Boggi, Ugo; van Laarhoven, Hanneke W M; Szentesi, Andrea; Eross, Bálint; Capretti, Giovanni; Schöttker, Ben; Skieceviciene, Jurgita; Aoki, Mateus Nóbrega; van Eijck, Casper H J; Cavestro, Giulia Martina; Canzian, Federico; Campa, Daniele.
Afiliación
  • Peduzzi G; Department of Biology, University of Pisa, 56126, Pisa, Italy.
  • Archibugi L; Digestive and Liver Disease Unit, Sant'Andrea Hospital, Rome, Italy.
  • Katzke V; Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Milan, Italy.
  • Gentiluomo M; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Capurso G; Department of Biology, University of Pisa, 56126, Pisa, Italy.
  • Milanetto AC; Digestive and Liver Disease Unit, Sant'Andrea Hospital, Rome, Italy.
  • Gazouli M; Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Milan, Italy.
  • Goetz M; Department DISCOG, University of Padova, Padua, Italy.
  • Brenner H; Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Vermeulen RCH; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
  • Talar-Wojnarowska R; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Vanella G; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
  • Tavano F; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Lucchesi M; University of Utrecht, Utrecht, The Netherlands.
  • Mohelnikova-Duchonova B; Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.
  • Chen X; Digestive and Liver Disease Unit, Sant'Andrea Hospital, Rome, Italy.
  • Kiudelis V; Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Milan, Italy.
  • Hegyi P; Division of Gastroenterology and Research Laboratory, Fondazione IRCCS "Casa Sollievo Della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
  • Oliverius M; Oncology of Massa Carrara, Oncological Department, Azienda USL Toscana Nord Ovest, Carrara, Italy.
  • Stocker H; Department of Oncology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic.
  • Stornello C; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Vodickova L; Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.
  • Soucek P; Gastroenterology Department and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • Neoptolemos JP; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
  • Testoni SGG; Centre for Translational Medicine, Semmelweis University, Budapest, Hungary.
  • Morelli L; Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
  • Lawlor RT; János Szentágothai Research Center, University of Pécs, Pécs, Hungary.
  • Basso D; Surgery Clinic Third Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Izbicki JR; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Ermini S; Network Aging Research (NAR), Heidelberg University, Heidelberg, Germany.
  • Kupcinskas J; Digestive and Liver Disease Unit, Sant'Andrea Hospital, Rome, Italy.
  • Pezzilli R; Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Milan, Italy.
  • Boggi U; Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
  • van Laarhoven HWM; First Faculty of Medicine, Institute of Biology and Medical Genetics, Charles University, Prague, Czech Republic.
  • Szentesi A; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
  • Eross B; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
  • Capretti G; Department of General Surgery, University of Heidelberg, Heidelberg, Germany.
  • Schöttker B; Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Milan, Italy.
  • Skieceviciene J; General Surgery, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
  • Aoki MN; ARC-NET, Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy.
  • van Eijck CHJ; Department DIMED-Laboratory Medicine, University of Padova, Padua, Italy.
  • Cavestro GM; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
  • Canzian F; Blood Transfusion Service, Azienda Ospedaliero-Universitaria Meyer, Florence, Italy.
  • Campa D; Gastroenterology Department and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Sci Rep ; 12(1): 18100, 2022 10 27.
Article en En | MEDLINE | ID: mdl-36302831
The incidence of pancreatic ductal adenocarcinoma (PDAC) is different among males and females. This disparity cannot be fully explained by the difference in terms of exposure to known risk factors; therefore, the lower incidence in women could be attributed to sex-specific hormones. A two-phase association study was conducted in 12,387 female subjects (5436 PDAC cases and 6951 controls) to assess the effect on risk of developing PDAC of single nucleotide polymorphisms (SNPs) in 208 genes involved in oestrogen and pregnenolone biosynthesis and oestrogen-mediated signalling. In the discovery phase 14 polymorphisms showed a statistically significant association (P < 0.05). In the replication none of the findings were validated. In addition, a gene-based analysis was performed on the 208 selected genes. Four genes (NR5A2, MED1, NCOA2 and RUNX1) were associated with PDAC risk, but only NR5A2 showed an association (P = 4.08 × 10-5) below the Bonferroni-corrected threshold of statistical significance. In conclusion, despite differences in incidence between males and females, our study did not identify an effect of common polymorphisms in the oestrogen and pregnenolone pathways in relation to PDAC susceptibility. However, we validated the previously reported association between NR5A2 gene variants and PDAC risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Adenocarcinoma / Carcinoma Ductal Pancreático Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Adenocarcinoma / Carcinoma Ductal Pancreático Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido