Your browser doesn't support javascript.
loading
Real-Time Magnetic Resonance Imaging to Study Orthostatic Intolerance Mechanisms in Human Beings: Proof of Concept.
Gerlach, Darius A; Maier, Andrea; Manuel, Jorge; Bach, Anja; Hoff, Alex; Hönemann, Jan-Niklas; Heusser, Karsten; Voit, Dirk; Frahm, Jens; Jordan, Jens; Tank, Jens.
Afiliación
  • Gerlach DA; Institute of Aerospace Medicine German Aerospace Center (DLR) Cologne Germany.
  • Maier A; Department of Neurology University Hospital Aachen Aachen Germany.
  • Manuel J; Institute of Aerospace Medicine German Aerospace Center (DLR) Cologne Germany.
  • Bach A; Institute for Neuroradiology Hannover Medical School Hannover Germany.
  • Hoff A; Institute of Aerospace Medicine German Aerospace Center (DLR) Cologne Germany.
  • Hönemann JN; Institute of Aerospace Medicine German Aerospace Center (DLR) Cologne Germany.
  • Heusser K; Institute of Aerospace Medicine German Aerospace Center (DLR) Cologne Germany.
  • Voit D; Department of Internal Medicine III, Division of Cardiology, Pneumology, Angiology, and Intensive Care University of Cologne Germany.
  • Frahm J; Institute of Aerospace Medicine German Aerospace Center (DLR) Cologne Germany.
  • Jordan J; Biomedical NMR Max Planck Institute for Multidisciplinary Sciences Göttingen Germany.
  • Tank J; Biomedical NMR Max Planck Institute for Multidisciplinary Sciences Göttingen Germany.
J Am Heart Assoc ; 11(21): e026437, 2022 11.
Article en En | MEDLINE | ID: mdl-36300662
Background Discerning the mechanisms driving orthostatic symptoms in human beings remains challenging. Therefore, we developed a novel approach combining cardiac and cerebral real-time magnetic resonance imaging, beat-to-beat physiological monitoring, and orthostatic stress testing through lower-body negative pressure (LBNP). We conducted a proof-of-concept study in a patient with severe orthostatic hypotension. Methods and Results We included a 46-year-old man with pure autonomic failure. Without and during -30 mmHg LBNP, we obtained 3T real-time magnetic resonance imaging of the cardiac short axis and quantitative flow measurements in the pulmonary trunk and middle cerebral artery. Blood pressure was 118/74 mmHg during supine rest and 58/35 mmHg with LBNP. With LBNP, left ventricular stroke volume decreased by 44.6%, absolute middle cerebral artery flow by 37.6%, and pulmonary trunk flow by 40%. Conclusions Combination of real-time magnetic resonance imaging, LBNP, and continuous blood pressure monitoring provides a promising new approach to study orthostatic intolerance mechanisms in human beings.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intolerancia Ortostática Límite: Humans / Male / Middle aged Idioma: En Revista: J Am Heart Assoc Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intolerancia Ortostática Límite: Humans / Male / Middle aged Idioma: En Revista: J Am Heart Assoc Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido