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A Janus Au-Polymersome Heterostructure with Near-Field Enhancement Effect for Implant-Associated Infection Phototherapy.
Chen, Chuanshuang; Chu, Guangyu; He, Wanting; Liu, Yannan; Dai, Kai; Valdez, Jesus; Moores, Audrey; Huang, Pei; Wang, Zhaohong; Jin, Jiale; Guan, Ming; Jiang, Wenfeng; Mai, Yiyong; Ma, Dongling; Wang, Yue; Zhou, Yongfeng.
Afiliación
  • Chen C; School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
  • Chu G; Spine Lab, Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
  • He W; Énergie Materiaux et Telécommunications, Institut National de la Recherche Scientifique (INRS), 1650 Boulevard Lionel-Boulet, Varennes, QC, J3X 1P7, Canada.
  • Liu Y; Center for Advancing Electronics Dresden (cfaed) and Faculty of Chemistry and Food Chemistry, Technische Universität Dresden, Mommsenstrasse 4, 01069, Dresden, Germany.
  • Dai K; Department of Materials, School of Physics and Electronic Science, East China Normal University, Shanghai, 200241, China.
  • Valdez J; Facility for Electron Microscopy Research (FEMR), McGill University, Montréal, QC, H3A 037, Canada.
  • Moores A; Centre in Green Chemistry and Catalysis, Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, QC, H3A 0B8, Canada.
  • Huang P; Facility for Electron Microscopy Research (FEMR), McGill University, Montréal, QC, H3A 037, Canada.
  • Wang Z; Centre in Green Chemistry and Catalysis, Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, QC, H3A 0B8, Canada.
  • Jin J; School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
  • Guan M; School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
  • Jiang W; Spine Lab, Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
  • Mai Y; Spine Lab, Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
  • Ma D; School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
  • Wang Y; School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
  • Zhou Y; Énergie Materiaux et Telécommunications, Institut National de la Recherche Scientifique (INRS), 1650 Boulevard Lionel-Boulet, Varennes, QC, J3X 1P7, Canada.
Adv Mater ; 35(3): e2207950, 2023 Jan.
Article en En | MEDLINE | ID: mdl-36300600
Polymer-inorganic hybrid Janus nanoparticles (PI-JNPs) have attracted extensive attention due to their special structures and functions. However, achieving the synergistic enhancement of photochemical activity between polymer and inorganic moieties in PI-JNPs remains challenging. Herein, the construction of a novel Janus Au-porphyrin polymersome (J-AuPPS) heterostructure by a facile one-step photocatalytic synthesis is reported. The near-field enhancement (NFE) effect between porphyrin polymersome (PPS) and Au nanoparticles in J-AuPPS is achieved to enhance its near-infrared (NIR) light absorption and electric/thermal field intensity at their interface, which improves the energy transfer and energetic charge-carrier generation. Therefore, J-AuPPS shows a higher NIR-activated photothermal conversion efficiency (48.4%) and generates more singlet oxygen compared with non-Janus core-particle Au-PPS nanostructure (28.4%). As a result, J-AuPPS exhibits excellent dual-mode (photothermal/photodynamic) antibacterial and anti-biofilm performance, thereby significantly enhancing the in vivo therapeutic effect in an implant-associated-infection rat model. This work is believed to motivate the rational design of advanced hybrid JNPs with desirable NFE effect and further extend their biological applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanoestructuras / Nanopartículas / Nanopartículas del Metal Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanoestructuras / Nanopartículas / Nanopartículas del Metal Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania