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Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease.
Wiseman, Stewart J; Zhang, Jun-Fang; Gray, Calum; Hamid, Charlene; Valdés Hernández, Maria Del C; Ballerini, Lucia; Thrippleton, Michael J; Manning, Cameron; Stringer, Michael; Sleight, Emilie; Muñoz Maniega, Susana; Morgan, Alasdair; Cheng, Yajun; Arteaga, Carmen; Jaime Garcia, Dany; Clancy, Una; Doubal, Fergus N; Dhillon, Baljean; MacGillivray, Tom; Wu, Yun-Cheng; Wardlaw, Joanna M.
Afiliación
  • Wiseman SJ; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Zhang JF; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
  • Gray C; Edinburgh Imaging Facilities, Edinburgh Imaging, University of Edinburgh, UK.
  • Hamid C; Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Valdés Hernández MDC; Edinburgh Imaging Facilities, Edinburgh Imaging, University of Edinburgh, UK.
  • Ballerini L; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Thrippleton MJ; Edinburgh Imaging Facilities, Edinburgh Imaging, University of Edinburgh, UK.
  • Manning C; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Stringer M; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
  • Sleight E; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Muñoz Maniega S; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
  • Morgan A; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Cheng Y; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
  • Arteaga C; Edinburgh Imaging Facilities, Edinburgh Imaging, University of Edinburgh, UK.
  • Jaime Garcia D; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Clancy U; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Doubal FN; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
  • Dhillon B; Edinburgh Imaging Facilities, Edinburgh Imaging, University of Edinburgh, UK.
  • MacGillivray T; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Wu YC; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
  • Wardlaw JM; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
J Cereb Blood Flow Metab ; 43(2): 231-240, 2023 02.
Article en En | MEDLINE | ID: mdl-36300327
Cerebral small vessel disease (SVD) is a cause of stroke and dementia. Retinal capillary microvessels revealed by optical coherence tomography angiography (OCTA) are developmentally related to brain microvessels. We quantified retinal vessel density (VD) and branching complexity, investigating relationships with SVD lesions, white matter integrity on diffusion tensor imaging (DTI) and cerebrovascular reactivity (CVR) to CO2 in patients with minor stroke. We enrolled 123 patients (mean age 68.1 ± SD 9.9 years), 115 contributed retinal data. Right (R) and left (L) eyes are reported. After adjusting for age, eye disease, diabetes, blood pressure and image quality, lower VD remained associated with higher mean diffusivity (MD) (standardized ß; R -0.16 [95%CI -0.32 to -0.01]) and lower CVR (L 0.17 [0.03 to 0.31] and R 0.19 [0.02 to 0.36]) in normal appearing white matter (NAWM). Sparser branching remained associated with sub-visible white matter damage shown by higher MD (R -0.24 [-0.08 to -0.40]), lower fractional anisotropy (FA) (L 0.17 [0.01 to 0.33]), and lower CVR (R 0.20 [0.02 to 0.38]) in NAWM. OCTA-derived metrics provide evidence of microvessel abnormalities that may underpin SVD lesions in the brain.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Enfermedades de los Pequeños Vasos Cerebrales / Sustancia Blanca Tipo de estudio: Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: J Cereb Blood Flow Metab Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Enfermedades de los Pequeños Vasos Cerebrales / Sustancia Blanca Tipo de estudio: Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: J Cereb Blood Flow Metab Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos