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Surgical Repair of Truncus Arteriosus: A Long-Term Hemodynamic Assessment.
Martín de Miguel, Irene; Jain, C Charles; Egbe, Alexander C; Hagler, Donald J; Connolly, Heidi M; Miranda, William R.
Afiliación
  • Martín de Miguel I; Department of Cardiovascular Medicine, 6915Mayo Clinic, Rochester, MN, USA.
  • Jain CC; Department of Cardiovascular Medicine, 6915Mayo Clinic, Rochester, MN, USA.
  • Egbe AC; Department of Cardiovascular Medicine, 6915Mayo Clinic, Rochester, MN, USA.
  • Hagler DJ; Department of Cardiovascular Medicine, 6915Mayo Clinic, Rochester, MN, USA.
  • Connolly HM; Department of Cardiovascular Medicine, 6915Mayo Clinic, Rochester, MN, USA.
  • Miranda WR; Department of Cardiovascular Medicine, 6915Mayo Clinic, Rochester, MN, USA.
World J Pediatr Congenit Heart Surg ; 13(6): 716-722, 2022 11.
Article en En | MEDLINE | ID: mdl-36300270
Background: Unrepaired truncus arteriosus (TA) carries poor prognosis due to complications of unrestricted pulmonary flow, truncal valve insufficiency, and pulmonary vascular disease. Currently, the hemodynamic profile of adults late after TA repair is unknown. We reviewed the hemodynamics, prevalence, and pathophysiology of pulmonary hypertension (PH) in this population. Methods: Eighteen adult patients with repaired TA who underwent cardiac catheterization at Mayo Clinic, MN, between 1997 and 2021 were identified. PH was defined as either precapillary (mean pulmonary artery pressure [mPAP] ≥25 mm Hg, pulmonary artery wedge pressure [PAWP] ≤15 mm Hg, and pulmonary vascular resistance [PVR] >3 Wood units), isolated postcapillary (mPAP ≥25, PAWP >15, PVR ≤3), or combined (mPAP ≥25, PAWP >15, and PVR >3). Diastolic pressure and transpulmonary gradients were used as ancillary data for classification. Results: Mean age at catheterization was 34 ± 10 years. Mean right ventricular (RV) systolic pressure was 82 ± 22.6 mm Hg, mean right and left mPAPs 28.1 ± 16.2 and 27.9 ± 11.9 mm Hg, respectively. Seven patients (41.2%) had PAWP >15 mm Hg and, among those undergoing arterial catheterization, 7 (53.8%) had a left ventricular (LV) end-diastolic pressure >15 mm Hg. PH was diagnosed in 13 patients (72.2%): 6 (33.3%) precapillary, 4 (22.2%) isolated postcapillary, and 3 (16.7%) combined. PAWP >15 mm Hg was associated with male sex (P = .049),
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tronco Arterial Persistente / Hipertensión Pulmonar Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Male Idioma: En Revista: World J Pediatr Congenit Heart Surg Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tronco Arterial Persistente / Hipertensión Pulmonar Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Male Idioma: En Revista: World J Pediatr Congenit Heart Surg Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos