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Comparative Evaluation of Tumor-Infiltrating Lymphocytes in Companion Animals: Immuno-Oncology as a Relevant Translational Model for Cancer Therapy.
Pinard, Christopher J; Lagree, Andrew; Lu, Fang-I; Klein, Jonathan; Oblak, Michelle L; Salgado, Roberto; Cardenas, Juan Carlos Pinto; Brunetti, Barbara; Muscatello, Luisa Vera; Sarli, Giuseppe; Foschini, Maria Pia; Hardas, Alexandros; Castillo, Simon P; AbdulJabbar, Khalid; Yuan, Yinyin; Moore, David A; Tran, William T.
Afiliación
  • Pinard CJ; Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.
  • Lagree A; Radiogenomics Laboratory, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada.
  • Klein J; Odette Cancer Program, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada.
  • Oblak ML; Radiogenomics Laboratory, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada.
  • Salgado R; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Cardenas JCP; Department of Radiation Oncology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
  • Brunetti B; Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.
  • Muscatello LV; Division of Research, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.
  • Sarli G; Department of Pathology, GZA-ZNA Hospitals, 2610 Antwerp, Belgium.
  • Foschini MP; Department of Pathology, DIAGSA, Mexico City 53910, Mexico.
  • Hardas A; Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano dell'Emilia, Italy.
  • Castillo SP; Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano dell'Emilia, Italy.
  • AbdulJabbar K; Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano dell'Emilia, Italy.
  • Yuan Y; Department of Biomedical and Neuromotor Sciences, University of Bologna, 40127 Bologna, Italy.
  • Moore DA; Department of Pathobiology & Population Sciences, The Royal Veterinary College, Hertfordshire AL9 7TA, UK.
  • Tran WT; Centre for Evolution and Cancer, The Institute of Cancer Research, London SM2 5NG, UK.
Cancers (Basel) ; 14(20)2022 Oct 13.
Article en En | MEDLINE | ID: mdl-36291791
Despite the important role of preclinical experiments to characterize tumor biology and molecular pathways, there are ongoing challenges to model the tumor microenvironment, specifically the dynamic interactions between tumor cells and immune infiltrates. Comprehensive models of host-tumor immune interactions will enhance the development of emerging treatment strategies, such as immunotherapies. Although in vitro and murine models are important for the early modelling of cancer and treatment-response mechanisms, comparative research studies involving veterinary oncology may bridge the translational pathway to human studies. The natural progression of several malignancies in animals exhibits similar pathogenesis to human cancers, and previous studies have shown a relevant and evaluable immune system. Veterinary oncologists working alongside oncologists and cancer researchers have the potential to advance discovery. Understanding the host-tumor-immune interactions can accelerate drug and biomarker discovery in a clinically relevant setting. This review presents discoveries in comparative immuno-oncology and implications to cancer therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza