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Brain Perfusion Alterations Induced by Standalone and Combined Non-Invasive Brain Stimulation over the Dorsolateral Prefrontal Cortex.
Razza, Lais Boralli; da Silva, Pedro Henrique Rodrigues; Busatto, Geraldo F; Duran, Fábio Luis de Souza; Pereira, Juliana; De Smet, Stefanie; Klein, Izio; Zanão, Tamires A; Luethi, Matthias S; Baeken, Chris; Vanderhasselt, Marie-Anne; Buchpiguel, Carlos Alberto; Brunoni, André Russowsky.
Afiliación
  • Razza LB; Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil.
  • da Silva PHR; Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium.
  • Busatto GF; Ghent Experimental Psychiatry (GHEP) Lab, Ghent University, 9000 Ghent, Belgium.
  • Duran FLS; Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil.
  • Pereira J; Laboratório de Neuroimagem em Psiquiatria (LIM-21), Instituto de Psiquiatria, Faculdade de Medicina da Universidade de São Paulo, R. Dr. Ovidio Pires de Campos 785, São Paulo 05403-000, Brazil.
  • De Smet S; Laboratório de Neuroimagem em Psiquiatria (LIM-21), Instituto de Psiquiatria, Faculdade de Medicina da Universidade de São Paulo, R. Dr. Ovidio Pires de Campos 785, São Paulo 05403-000, Brazil.
  • Klein I; Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil.
  • Zanão TA; Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium.
  • Luethi MS; Ghent Experimental Psychiatry (GHEP) Lab, Ghent University, 9000 Ghent, Belgium.
  • Baeken C; Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil.
  • Vanderhasselt MA; Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil.
  • Buchpiguel CA; Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil.
  • Brunoni AR; Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium.
Biomedicines ; 10(10)2022 Sep 27.
Article en En | MEDLINE | ID: mdl-36289672
Non-invasive brain stimulation (NIBS) interventions are promising for the treatment of psychiatric disorders. Notwithstanding, the NIBS mechanisms of action over the dorsolateral prefrontal cortex (DLPFC), a hub that modulates affective and cognitive processes, have not been completely mapped. We aimed to investigate regional cerebral blood flow (rCBF) changes over the DLPFC and the subgenual anterior cingulate cortex (sgACC) of different NIBS protocols using Single-Photon Emission Computed Tomography (SPECT). A factorial, within-subjects, double-blinded study was performed. Twenty-three healthy subjects randomly underwent four sessions of NIBS applied once a week: transcranial direct current stimulation (tDCS), intermittent theta-burst stimulation (iTBS), combined tDCS + iTBS and placebo. The radiotracer 99m-Technetium-ethylene-cysteine-dimer was injected intravenously during the NIBS session, and SPECT neuroimages were acquired after the session. Results revealed that the combination of tDCS + iTBS increased right sgACC rCBF. Cathodal and anodal tDCS increased and decreased DLPFC rCBF, respectively, while iTBS showed no significant changes compared to the placebo. Our findings suggest that the combined protocol might optimize the activity in the right sgACC and encourage future trials with neuropsychiatric populations. Moreover, mechanistic studies to investigate the effects of tDCS and iTBS over the DLPFC are required.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Guideline Idioma: En Revista: Biomedicines Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Guideline Idioma: En Revista: Biomedicines Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza