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The Decrease in Serum sRAGE Levels Upon Smoking is Associated with Activated Neutrophils.
Wiersma, Valerie R; Hoonhorst, Susan J M; Ten Hacken, Nick H T; van den Berge, Maarten; Slebos, Dirk-Jan; Pouwels, Simon D.
Afiliación
  • Wiersma VR; Department of Hematology, Cancer Research Center Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Hoonhorst SJM; Department of Pulmonary Diseases, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
  • Ten Hacken NHT; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
  • van den Berge M; Department of Pulmonary Diseases, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
  • Slebos DJ; Department of Pulmonary Diseases, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
  • Pouwels SD; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Lung ; 200(6): 687-690, 2022 12.
Article en En | MEDLINE | ID: mdl-36282357
The serum level of the soluble Receptor for Advanced Glycation End-products (sRAGE) is a promising blood biomarker for the development, severity, and progression of chronic obstructive pulmonary disease (COPD). However, cigarette smoking causes a nearly instant drop in circulating sRAGE levels, strongly impacting on the variability in sRAGE levels. In the current study, we investigated the possible mechanism behind the sudden drop in sRAGE upon smoking. We showed that the number of activated neutrophils in blood significantly increases within two hours upon smoking three cigarettes within one hour. Furthermore, an increased expression of the leukocyte activation marker CD11b, which is a known ligand for RAGE, was observed upon smoking. Additionally, the in vitro activation of neutrophils increased their capacity to bind sRAGE. Together, these data indicate that smoking activates neutrophils in the circulation with concomitant upregulation of the RAGE ligand CD11b, leading to reduced levels of sRAGE in serum.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Inmunológicos / Neutrófilos Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Lung Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Inmunológicos / Neutrófilos Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Lung Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos