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The role of short-term grass pollen exposure in food skin-prick test reactivity, food allergy, and eczema flares in children.
Idrose, Nur Sabrina; Lodge, Caroline J; Peters, Rachel L; Douglass, Jo A; Koplin, Jennifer J; Lowe, Adrian J; Perrett, Kirsten P; Tang, Mimi L K; Newbigin, Ed J; Abramson, Michael J; Erbas, Bircan; Vicendese, Don; Dharmage, Shyamali C.
Afiliación
  • Idrose NS; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, Carlton, Victoria, Australia.
  • Lodge CJ; Centre for Food and Allergy Research (CFAR), Murdoch Children's Research Institute, Parkville, Victoria, Australia.
  • Peters RL; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, Carlton, Victoria, Australia.
  • Douglass JA; Centre for Food and Allergy Research (CFAR), Murdoch Children's Research Institute, Parkville, Victoria, Australia.
  • Koplin JJ; Department of Pediatrics, The University of Melbourne, Victoria, Australia.
  • Lowe AJ; Department of Clinical Immunology and Allergy, Royal Melbourne Hospital, Parkville, Victoria, Australia.
  • Perrett KP; Department of Medicine, University of Melbourne, Victoria, Australia.
  • Tang MLK; Centre for Food and Allergy Research (CFAR), Murdoch Children's Research Institute, Parkville, Victoria, Australia.
  • Newbigin EJ; Department of Pediatrics, The University of Melbourne, Victoria, Australia.
  • Abramson MJ; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, Carlton, Victoria, Australia.
  • Erbas B; Centre for Food and Allergy Research (CFAR), Murdoch Children's Research Institute, Parkville, Victoria, Australia.
  • Vicendese D; Centre for Food and Allergy Research (CFAR), Murdoch Children's Research Institute, Parkville, Victoria, Australia.
  • Dharmage SC; Department of Pediatrics, The University of Melbourne, Victoria, Australia.
Pediatr Allergy Immunol ; 33(10): e13862, 2022 Oct.
Article en En | MEDLINE | ID: mdl-36282135
BACKGROUND: While the relationship between pollen and respiratory allergies is well-documented, the role of short-term pollen exposure in food allergy and eczema flares has not previously been explored. We aimed to investigate these associations in a population-based sample of children. METHODS: We investigated 1- (n = 1108) and 6-year-old (n = 675) children in the grass pollen season from the HealthNuts cohort. Grass pollen concentrations were considered on the day of testing (lag 0), up to three days before (lag 1-lag 3) and cumulatively (lag 0-3). Associations between grass pollen and food skin-prick test reactivity (SPT ≥ 2 mm at age 1 year and ≥ 3 mm at age 6 years), eczema flares, challenge-confirmed food allergy, reaction threshold to oral food challenges (OFC), and serum food-specific IgE levels were analyzed using either logistic or quantile regression models. Atopy and family history of allergic disease were considered as potent effect modifiers. RESULTS: Grass pollen at lag 0-3 (every 20 grains/m3 increase) was associated with an up to 1.2-fold increased odds of food SPT reactivity and eczema flares in 6-year-olds. In 1-year-olds, the associations were only observed for peanut in those with a family history of food allergy. Increasing grass pollen concentrations were associated with a lower reaction threshold to OFC and higher serum IgE levels in peanut-allergic 1-year-olds only. CONCLUSION: Increasing grass pollen concentration was associated with increased risk of food SPT reactivity and eczema flares in children. The associations in peanut-allergic infants may be related to immune activation and/or peanut and grass pollen cross-reactivity leading to a lower reaction threshold.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Eccema / Hipersensibilidad a los Alimentos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Child / Humans / Infant Idioma: En Revista: Pediatr Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA / PEDIATRIA Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Eccema / Hipersensibilidad a los Alimentos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Child / Humans / Infant Idioma: En Revista: Pediatr Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA / PEDIATRIA Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido