Synthesis, conformation and cytotoxic activity of short hybrid peptides containing conformationally constrained 1-(aminomethyl)cyclohexanecarboxylic acid and gabapentin.

Ur Rahim, Junaid; Ahmad, Syed Mudabir; Amin, Tanzeeba; Chowdhary, Rubina; Goswami, Anindya; Rai, Rajkishor

Ur Rahim, Junaid; Ahmad, Syed Mudabir; Amin, Tanzeeba; Chowdhary, Rubina; Goswami, Anindya; Rai, Rajkishor.

Afiliación

Ur Rahim J; Natural Products and Medicinal Chemistry Division (NPMC), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Jammu and Kashmir 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Ahmad SM; Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Jammu and Kashmir 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Amin T; Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Jammu and Kashmir 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Chowdhary R; Natural Products and Medicinal Chemistry Division (NPMC), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Jammu and Kashmir 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Goswami A; Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Jammu and Kashmir 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: agoswami@iiim.res.in.
Rai R; Natural Products and Medicinal Chemistry Division (NPMC), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Jammu and Kashmir 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: raj@iiim.res.in.

Peptides ; 158: 170897, 2022 12.

Article en En | MEDLINE | ID: mdl-36279986

Asunto(s)

Aminoácidos; Neoplasias de la Mama; Humanos; Femenino; Gabapentina; Células HEK293; Aminoácidos/química; Enlace de Hidrógeno; Cristalografía por Rayos X; Modelos Moleculares; Péptidos/química

Palabras clave

Apoptosis; C(6)/C(7) conformation; ROS; Short peptides; ß/Î³ hybrid peptides

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Aminoácidos Límite: Female / Humans Idioma: En Revista: Peptides Año: 2022 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos

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