A lysine residue from an extracellular turret switches the ion preference in a Cav3 T-Type channel from calcium to sodium ions.

Guan, Wendy; Orellana, Kaidy G; Stephens, Robert F; Zhorov, Boris S; Spafford, J David

Guan, Wendy; Orellana, Kaidy G; Stephens, Robert F; Zhorov, Boris S; Spafford, J David.

Afiliación

Guan W; Department of Biology, University of Waterloo, Waterloo, Ontario, Canada.
Orellana KG; Department of Biology, University of Waterloo, Waterloo, Ontario, Canada.
Stephens RF; Department of Biology, University of Waterloo, Waterloo, Ontario, Canada.
Zhorov BS; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia; Almazov National Medical Research Centre, St. Petersburg, Russia.
Spafford JD; Department of Biology, University of Waterloo, Waterloo, Ontario, Canada. Electronic address: david.spafford@uwaterloo.ca.

J Biol Chem ; 298(12): 102621, 2022 12.

Article en En | MEDLINE | ID: mdl-36272643

Asunto(s)

Canales de Calcio Tipo T; Calcio; Lisina; Sodio; Ácido Aspártico; Calcio/química; Ácido Glutámico; Iones; Lisina/química; Sodio/química; Lymnaea; Animales; Canales de Calcio Tipo T/química

Palabras clave

AlphaFold2 molecular modeling; calcium channels; ion selectivity; patch clamp; sodium channels

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sodio / Calcio / Canales de Calcio Tipo T / Lisina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Biol Chem Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos

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