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Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion.
Kaminskiy, Yaroslav; Kuznetsova, Varvara; Kudriaeva, Anna; Zmievskaya, Ekaterina; Bulatov, Emil.
Afiliación
  • Kaminskiy Y; Department of Oncology and Pathology, Karolinska Institutet, SciLifeLab, Solna, Sweden.
  • Kuznetsova V; Laboratory of Transplantation Immunology, National Research Centre for Hematology, Moscow, Russia.
  • Kudriaeva A; Laboratory of Transplantation Immunology, National Research Centre for Hematology, Moscow, Russia.
  • Zmievskaya E; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
  • Bulatov E; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
Front Immunol ; 13: 971045, 2022.
Article en En | MEDLINE | ID: mdl-36268015
FOXP1 is ubiquitously expressed in the human body and is implicated in both physiological and pathological processes including cancer. However, despite its importance the role of FOXP1 in T-cells has not been extensively studied. Although relatively few phenotypic and mechanistic details are available, FOXP1 role in T-cell quiescence and differentiation of CD4+ subsets has recently been established. FOXP1 prevents spontaneous T-cell activation, preserves memory potential, and regulates the development of follicular helper and regulatory T-cells. Moreover, there is growing evidence that FOXP1 also regulates T-cell exhaustion. Altogether this makes FOXP1 a crucial and highly undervalued regulator of T-cell homeostasis. In this review, we discuss the biology of FOXP1 with a focus on discoveries made in T-cells in recent years.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Represoras / Factores de Transcripción Forkhead Límite: Humans Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Suiza
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Represoras / Factores de Transcripción Forkhead Límite: Humans Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Suiza