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Increased levels of serum adenosine deaminase and increased risk of diabetic peripheral neuropathy in type 2 diabetes.
Yu, Chao; Zhuang, Lei; Xu, Feng; Zhao, Li-Hua; Wang, Xiao-Hua; Wang, Chun-Hua; Ning, Li-Yan; Zhang, Xiu-Lin; Zhang, Dong-Mei; Wang, Xue-Qin; Su, Jian-Bin.
Afiliación
  • Yu C; Department of Clinical Laboratory, Affiliated Hospital 2 of Nantong University, First People's Hospital of Nantong City, Nantong, China.
  • Zhuang L; Department of Endocrinology, Second People's Hospital of Nantong City, Nantong, China.
  • Xu F; Department of Endocrinology, Affiliated Hospital 2 of Nantong University, First People's Hospital of Nantong City, Nantong, China.
  • Zhao LH; Department of Endocrinology, Affiliated Hospital 2 of Nantong University, First People's Hospital of Nantong City, Nantong, China.
  • Wang XH; Department of Endocrinology, Affiliated Hospital 2 of Nantong University, First People's Hospital of Nantong City, Nantong, China.
  • Wang CH; Department of Endocrinology, Affiliated Hospital 2 of Nantong University, First People's Hospital of Nantong City, Nantong, China.
  • Ning LY; Department of Administration, Affiliated Hospital 2 of Nantong University, First People's Hospital of Nantong City, Nantong, China.
  • Zhang XL; Department of Clinical Laboratory, Affiliated Hospital 2 of Nantong University, First People's Hospital of Nantong City, Nantong, China.
  • Zhang DM; Medical Research Center, Affiliated Hospital 2 of Nantong University, First People's Hospital of Nantong City, Nantong, China.
  • Wang XQ; Department of Endocrinology, Affiliated Hospital 2 of Nantong University, First People's Hospital of Nantong City, Nantong, China.
  • Su JB; Department of Endocrinology, Affiliated Hospital 2 of Nantong University, First People's Hospital of Nantong City, Nantong, China.
Front Endocrinol (Lausanne) ; 13: 997672, 2022.
Article en En | MEDLINE | ID: mdl-36267565
Background: Increased serum adenosine deaminase (ADA) levels have been shown to be involved in metabolic abnormalities and immune disequilibrium, which may in turn contribute to inflammatory diseases. This study aimed to determine whether increased serum ADA levels are related to diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes (T2D). Methods: This study was part of a series exploring the potential risks for DPN. All patients received DPN assessment based on neuropathic symptoms, neuropathic signs, and nerve conduction studies to calculate the composite Z score of nerve latency, amplitude and conduction velocity (NCV). DPN was confirmed by both at least a presentation of neuropathic symptoms/signs and an abnormal nerve conduction index. Serum ADA levels were also synchronously detected. Results: A total of 384 eligible patients with T2D were recruited for this study, and 24.5% (n=94) were determined to have DPN. Increases in serum ADA levels were closely associated with increases in composite Z score of latency (ß=0.263, t=5.273, p<0.001) and decreases in composite Z score of amplitude (ß=-0.126, t=-2.352, p=0.019) and NCV (ß=-0.201, t=-3.841, p<0.001) after adjusting for other clinical covariates. Moreover, each 5 U/L increase in serum ADA levels was associated with a 1.781-fold increased adjusted odds ratio of having DPN (95% confidence interval: 1.271-2.495). Furthermore, the optimal cut-off value of serum ADA levels to discriminate DPN was ≥14.2 U/L (sensitivity=59.57%, specificity=75.52% and Youden index=0.351) after analysis by receiver operating characteristic curve. Conclusions: Increased serum ADA levels may be a potential risk factor for DPN in patients with T2D.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Neuropatías Diabéticas Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Neuropatías Diabéticas Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza