Catch-enrich-release approach for amine-containing natural products.

Müller, Michelle Jessy; Dorst, Andrea; Paulus, Constanze; Khan, Imran; Sieber, Simon

Müller, Michelle Jessy; Dorst, Andrea; Paulus, Constanze; Khan, Imran; Sieber, Simon.

Afiliación

Müller MJ; Department of Chemistry, University of Zurich, 8057 Zurich, Switzerland. simon.sieber@uzh.ch.
Dorst A; Department of Chemistry, University of Zurich, 8057 Zurich, Switzerland. simon.sieber@uzh.ch.
Paulus C; Department of Chemistry, University of Zurich, 8057 Zurich, Switzerland. simon.sieber@uzh.ch.
Khan I; Department of Chemistry, University of Zurich, 8057 Zurich, Switzerland. simon.sieber@uzh.ch.
Sieber S; Department of Chemistry, University of Zurich, 8057 Zurich, Switzerland. simon.sieber@uzh.ch.

Chem Commun (Camb) ; 58(90): 12560-12563, 2022 Nov 10.

Article en En | MEDLINE | ID: mdl-36264220

RESUMEN

Amine-containing natural products are an important class of therapeutic compounds. Herein, we report a chemoselective approach to catch and enrich amine-containing natural products, and release them as underivatized compounds. The strategy exploits the selectivity of the enzyme legumain for the specific release of amine-containing natural products.

Asunto(s)

Aminas; Productos Biológicos

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos Biológicos / Aminas Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido

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