The high toxicity of DSB-clusters modelling high-LET-DNA damage derives from inhibition of c-NHEJ and promotion of alt-EJ and SSA despite increases in HR.

Mladenova, Veronika; Mladenov, Emil; Chaudhary, Shipra; Stuschke, Martin; Iliakis, George

Mladenova, Veronika; Mladenov, Emil; Chaudhary, Shipra; Stuschke, Martin; Iliakis, George.

Afiliación

Mladenova V; Department of Radiation Therapy, Division of Experimental Radiation Biology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Mladenov E; Institute of Medical Radiation Biology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Chaudhary S; Department of Radiation Therapy, Division of Experimental Radiation Biology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Stuschke M; Institute of Medical Radiation Biology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Iliakis G; Institute of Medical Radiation Biology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Front Cell Dev Biol ; 10: 1016951, 2022.

Article en En | MEDLINE | ID: mdl-36263011

Palabras clave

DNA end-processing; SCAs-formation; double-strand break clusters (DSB-clusters); high-LET ionizing radiation; mFISH

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Cell Dev Biol Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza

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