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Using 157Gd doped carbon and 157GdF4 nanoparticles in proton-targeted therapy for effectiveness enhancement and thermal neutron reduction: a simulation study.
Tabbakh, Farshid; Hosmane, Narayan S; Tajudin, Suffian M; Ghorashi, Amir-Hossein; Morshedian, Nader.
Afiliación
  • Tabbakh F; Plasma and Nuclear Fusion Research School, Nuclear Science and Technology Research Institute, Tehran, 14155-1339, Iran. ftabbakh2000@yahoo.com.
  • Hosmane NS; Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL, 60115-2862, USA.
  • Tajudin SM; Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Kuala Terengganu, Terengganu, Malaysia.
  • Ghorashi AH; Plasma and Nuclear Fusion Research School, Nuclear Science and Technology Research Institute, Tehran, 14155-1339, Iran.
  • Morshedian N; Plasma and Nuclear Fusion Research School, Nuclear Science and Technology Research Institute, Tehran, 14155-1339, Iran.
Sci Rep ; 12(1): 17404, 2022 10 18.
Article en En | MEDLINE | ID: mdl-36258012
There are two major problems in proton therapy. (1) In comparison with the gamma-ray therapy, proton therapy has only ~ 10% greater biological effectiveness, and (2) the risk of the secondary neutrons in proton therapy is another unsolved problem. In this report, the increase of biological effectiveness in proton therapy has been evaluated with better performance than 11B in the presence of two proposed nanomaterials of 157GdF4 and 157Gd doped carbon with the thermal neutron reduction due to the presence of 157Gd isotope. The present study is based on the microanalysis calculations using GEANT4 Monte Carlo tool and GEANT4-DNA package for the strand breaks measurement. It was found that the proposed method will increase the effectiveness corresponding to the alpha particles by more than 100% and also, potentially will decrease the thermal neutrons fluence, significantly. Also, in this work, a discussion is presented on a significant contribution of the secondary alpha particles in total effectiveness in proton therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas / Terapia de Protones Tipo de estudio: Health_economic_evaluation Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas / Terapia de Protones Tipo de estudio: Health_economic_evaluation Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido