Modeling Type-1 Iodothyronine Deiodinase with Peptide-Based Aliphatic Diselenides: Potential Role of Highly Conserved His and Cys Residues as a General Acid Catalyst.

Arai, Kenta; Toba, Haruka; Yamamoto, Nozomi; Ito, Mao; Mikami, Rumi

Arai, Kenta; Toba, Haruka; Yamamoto, Nozomi; Ito, Mao; Mikami, Rumi.

Afiliación

Arai K; Department of Chemistry, School of Science, Tokai University Kitakaname, Hiratsuka-shi, Kanagawa, 259-1292, Japan.
Toba H; Institute of Advanced Biosciences, Tokai University Kitakaname, Hiratsuka-shi, Kanagawa, 259-1292, Japan.
Yamamoto N; Department of Chemistry, School of Science, Tokai University Kitakaname, Hiratsuka-shi, Kanagawa, 259-1292, Japan.
Ito M; Department of Chemistry, School of Science, Tokai University Kitakaname, Hiratsuka-shi, Kanagawa, 259-1292, Japan.
Mikami R; Department of Chemistry, School of Science, Tokai University Kitakaname, Hiratsuka-shi, Kanagawa, 259-1292, Japan.

Chemistry ; 29(3): e202202387, 2023 Jan 12.

Article en En | MEDLINE | ID: mdl-36254793

Asunto(s)

Yoduro Peroxidasa; Tiroxina; Yoduro Peroxidasa/química; Tiroxina/química; Halógenos/química; Catálisis; Fenoles; Triyodotironina/química

Palabras clave

deiodination; enzyme model; halogen bond; thyroid hormone; Î³-turn

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiroxina / Yoduro Peroxidasa Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania

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