Your browser doesn't support javascript.
loading
Regional gastrointestinal transit times in patients with chronic pancreatitis.
Larsen, Isabelle M; Holten-Rossing, Sidse; Mark, Esben Bolvig; Poulsen, Jakob Lykke; Krogh, Klaus; Scott, S Mark; Olesen, Søren Schou; Drewes, Asbjørn Mohr.
Afiliación
  • Larsen IM; Mech-Sense and Centre for Pancreatic Diseases, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.
  • Holten-Rossing S; Mech-Sense and Centre for Pancreatic Diseases, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.
  • Mark EB; Mech-Sense and Centre for Pancreatic Diseases, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.
  • Poulsen JL; Mech-Sense and Centre for Pancreatic Diseases, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.
  • Krogh K; Neurogastroenterology Unit, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
  • Scott SM; Clinical Institute, Aarhus University, Aarhus Denmark.
  • Olesen SS; Neurogastroenterology Group (GI Physiology Unit), Centre for Neuroscience, Surgery & Trauma, Blizard Institute, Queen Mary University of London, London, UK.
  • Drewes AM; Mech-Sense and Centre for Pancreatic Diseases, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.
Medicine (Baltimore) ; 101(41): e31141, 2022 Oct 14.
Article en En | MEDLINE | ID: mdl-36253998
The mechanisms behind disrupted gastrointestinal (GI) motor function in patients with chronic pancreatitis (CP) have not been fully elucidated. We compared regional transit times in patients with CP to those in healthy controls, and investigated whether they were associated with diabetes mellitus, exocrine dysfunction, opioid treatment or quality of life. Twenty-eight patients with CP and 28 age- and gender-matched healthy controls were included. Regional GI transit times were determined using the 3D-Transit system, which consists of an ingestible electromagnetic capsule and a detector worn in an abdominal belt for 5 days. Exocrine function was assessed using the fecal elastase-1 test, and quality of life was assessed using the European Organization for Research and Treatment of Cancer questionnaire. Transit times were analyzed for associations with diabetes mellitus, exocrine pancreatic insufficiency (EPI), opioid treatment and quality of life. Compared with healthy controls, patients with CP had prolonged transit times in the small intestine (6.6 ±â€…1.8 vs 4.8 ±â€…2.2 hours, P = .006), colon (40 ±â€…23 vs 28 ±â€…26 hours, P = .02), and total GI tract (52 ±â€…26 vs 36 ±â€…26 hours, P = .02). There was no difference in gastric emptying time (4.8 ±â€…5.2 vs 3.1 ±â€…1.3 hours, P = .9). No associations between transit times and diabetes, EPI, or opioid consumption were found (all P > .05). Quality of life and associated functional and symptom subscales were not associated with transit times, except for diarrhea (P = .03). Patients with CP have prolonged small intestinal and colonic transit times. However, these alterations do not seem to be mediated by diabetes, EPI, or opioid consumption.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Insuficiencia Pancreática Exocrina / Pancreatitis Crónica Tipo de estudio: Etiology_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Medicine (Baltimore) Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Insuficiencia Pancreática Exocrina / Pancreatitis Crónica Tipo de estudio: Etiology_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Medicine (Baltimore) Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Estados Unidos