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Mussel-inspired adhesive zwitterionic composite hydrogel with antioxidant and antibacterial properties for wound healing.
Wang, Shiyu; Liu, Ruiqi; Bi, Siwei; Zhao, Xueshan; Zeng, Guixiang; Li, Xiaoyi; Wang, Haibo; Gu, Jun.
Afiliación
  • Wang S; Department of Cardiovascular surgery, West China Hospital, Sichuan University, China; College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China.
  • Liu R; Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, China.
  • Bi S; Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, China.
  • Zhao X; Department of Cardiovascular surgery, West China Hospital, Sichuan University, China.
  • Zeng G; Department of Pediatrics, No. 903 Hospital of PLA Joint Logistic Support Force, Hangzhou 310013, China.
  • Li X; College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China.
  • Wang H; College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China.
  • Gu J; Department of Cardiovascular surgery, West China Hospital, Sichuan University, China. Electronic address: gujun@wchscu.cn.
Colloids Surf B Biointerfaces ; 220: 112914, 2022 Dec.
Article en En | MEDLINE | ID: mdl-36252533
The skin can be easily injured and attacked by external pathogens, leading to wound infection and wound healing delay. Traditional dressings adhere to wounds only and can cause secondary damage to the new epithelium and bleeding. Herein, a highly adhesive zwitterionic composite hydrogel wound dressing (PDA/PSBMA/NFC/Zn2+ [PSNZn]) with outstanding antibacterial properties, good biocompatibility and excellent rheological properties was prepared by introducing zinc ion-loaded polydopamine (PDA)-coated nanofibrillated cellulose into a covalently-crosslinked sulfobetaine methacrylate (SBMA) network. In vitro and in vivo experiments showed the broad-spectrum and lasting antibacterial activity of the PSNZn composite hydrogel against Escherichia coli and Staphylococcus aureus. In summary, the PSNZn composite hydrogel is an excellent wound dressing candidate with efficient antibacterial properties, high adhesion, excellent biocompatibility and good rheological properties.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Antioxidantes Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Antioxidantes Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos