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Nano-visualization of the in vitro antiviral activity of black tea based on production area using a liposome-based virus membrane model.
Iijima, Masumi; Kawaguchi, Atsushi; Ogura, Yukino; Yoshimoto, Ryotaro; Kaneda, Moemi; Kera, Kota; Kuroda, Shun'ichi; Nakayama, Tsutomu.
Afiliación
  • Iijima M; Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Setagaya, Tokyo, 156-8502 Japan.
  • Kawaguchi A; Department of Infection Biology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575 Japan.
  • Ogura Y; Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
  • Yoshimoto R; Department of Infection Biology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575 Japan.
  • Kaneda M; Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
  • Kera K; Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Setagaya, Tokyo, 156-8502 Japan.
  • Kuroda S; Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Setagaya, Tokyo, 156-8502 Japan.
  • Nakayama T; Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Setagaya, Tokyo, 156-8502 Japan.
Biosci Biotechnol Biochem ; 86(12): 1658-1669, 2022 Nov 23.
Article en En | MEDLINE | ID: mdl-36243901
Black tea extracts (BTEs) from four different production areas showed a higher aggregation strength for phosphatidylcholine-based liposomes containing cholesterol used as a viral membrane model. Furthermore, the anti-influenza A virus (IAV) activity of each BTE in vitro demonstrated that although Sri Lanka, Kenya, and Assam had higher anti-IAV activities, Darjeeling had a lower anti-IAV activity, showing a correlation between each BTE and the liposome aggregation strength. Moreover, the antiviral activity strength of BTEs was consistent with the antioxidant activity strength of BTEs, suggesting that the component(s) in black tea that exhibits antioxidant activity would also be the component(s) that accounts for its antiviral activity. Thus, our results propose that BTEs exert their antiviral effects by binding not only hemagglutinin and neuraminidase but also viral membranes directly, especially "cholesterol-rich lipid rafts" and affect the membrane structure, causing the virus to aggregate, thereby inhibiting infection of the host cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Camellia sinensis Idioma: En Revista: Biosci Biotechnol Biochem Asunto de la revista: BIOQUIMICA / BIOTECNOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Camellia sinensis Idioma: En Revista: Biosci Biotechnol Biochem Asunto de la revista: BIOQUIMICA / BIOTECNOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido