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Lithium chloride stimulates bone formation in extraction socket repair in rats.
Duarte, Poliana Mendes; Miranda, Tamires Szeremeske; Marins, Letícia Macedo; da Silva, João Ricardo Batistão; de Souza Malta, Fernando; de Vasconcelos Gurgel, Bruno César; Napimoga, Marcelo Henrique.
Afiliación
  • Duarte PM; Department of Periodontology, Dental Research Division, Guarulhos University, São Paulo, Brazil. PMendesDuarte@dental.ufl.edu.
  • Miranda TS; Department of Periodontology, College of Dentistry, University of Florida, 1600 SW Archer Rd., Room D10-6, Gainesville, FL, 32610, USA. PMendesDuarte@dental.ufl.edu.
  • Marins LM; Department of Periodontology, Dental Research Division, Guarulhos University, São Paulo, Brazil.
  • da Silva JRB; Department of Periodontology, São Judas Tadeu University, São Paulo, SP, Brazil.
  • de Souza Malta F; Department of Periodontology, Dental Research Division, Guarulhos University, São Paulo, Brazil.
  • de Vasconcelos Gurgel BC; Faculdade São Leopoldo Mandic, Instituto São Leopoldo Mandic, Área de Imunologia, Campinas, SP, Brazil.
  • Napimoga MH; Department of Periodontology, Dental Research Division, Guarulhos University, São Paulo, Brazil.
Oral Maxillofac Surg ; 2022 Oct 15.
Article en En | MEDLINE | ID: mdl-36242702
PURPOSE: Previous evidence shows that lithium chloride (LiCl), a suppressor of glycogen synthase kinase-3ß (GSK-3ß), may enhance bone formation in several medical and dental conditions. Thus, the purpose of the current study was to assess the effects of LiCl on extraction socket repair in rats. METHODS: Thirty rats were randomly assigned into a control group (administration of water; n = 15) or a LiCl group (administration of 150 mg/kg of LiCl; n = 15). LiCl and water were given every other day, starting at 7 days before the extraction of upper first molars until the end of each experiment period. Histological sections from five rats per group were obtained at 10, 20, and 30 days post-extractions. Histometrical analysis of newly formed bone (NB) and the levels of tartrate-resistant acid phosphatase (TRAP)-stained cells were evaluated at 10, 20, and 30 days post-extractions. Immunohistochemical staining for receptor activator of nuclear factor kappa-Β ligand (RANKL), osteoprotegerin (OPG), bone sialoprotein (BSP), osteocalcin (OCN), and osteopontin (OPN) was assessed at 10 days post-extractions. RESULTS: The LiCl group had a greater proportion of NB than the control group at 20 days (P < 0.05). At 30 days, the rate of TRAP-stained cells was lower in the LiCl group than in the control group (P < 0.05). At 10 days, the LiCl group presented stronger staining for OPG, BSP, OPN, and OCN, when compared to the control group (P < 0.05). CONCLUSION: Systemic LiCl enhanced extraction socket repair, stimulated an overall increase in bone formation markers, and restricted the levels of TRAP in rats.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oral Maxillofac Surg Asunto de la revista: ODONTOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oral Maxillofac Surg Asunto de la revista: ODONTOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania