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Alcohol Synthesis by Cobalt-Catalyzed Visible-Light-Driven Reductive Hydroformylation.
MacNeil, Connor S; Mendelsohn, Lauren N; Pabst, Tyler P; Hierlmeier, Gabriele; Chirik, Paul J.
Afiliación
  • MacNeil CS; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
  • Mendelsohn LN; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
  • Pabst TP; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
  • Hierlmeier G; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
  • Chirik PJ; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
J Am Chem Soc ; 144(42): 19219-19224, 2022 10 26.
Article en En | MEDLINE | ID: mdl-36240429
A cobalt-catalyzed reductive hydroformylation of terminal and 1,1-disubstituted alkenes is described. One-carbon homologated alcohols were synthesized directly from CO and H2, affording anti-Markovnikov products (34-87% yield) with exclusive regiocontrol (linear/branch >99:1) for minimally functionalized alkenes. Irradiation of the air-stable cobalt hydride, (dcype)Co(CO)2H (dcype = dicyclohexylphosphinoethane) with blue light generated the active catalyst that mediates alkene hydroformylation and subsequent aldehyde hydrogenation. Mechanistic origins of absolute regiocontrol were investigated by in situ monitoring of the tandem catalytic reaction using multinuclear NMR spectroscopy with syngas mixtures.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cobalto / Alquenos Idioma: En Revista: J Am Chem Soc Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cobalto / Alquenos Idioma: En Revista: J Am Chem Soc Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos