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Intra Articular Injection of Autologous Microfat and Platelets-Rich Plasma in the Treatment of Wrist Osteoarthritis: A Pilot Study.
Mayoly, Alice; Witters, Marie; Jouve, Elisabeth; Bec, Cécilia; Iniesta, Aurélie; Kachouh, Najib; Veran, Julie; Grimaud, Fanny; Zavarro, Anouck Coulange; Fernandez, Rémi; Bendahan, David; Giraudo, Laurent; Dumoulin, Chloé; Chagnaud, Christophe; Casanova, Dominique; Sabatier, Florence; Legré, Régis; Jaloux, Charlotte; Magalon, Jérémy.
Afiliación
  • Mayoly A; Department of Hand and Limb Reconstructive Surgery, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, 13005 Marseille, France.
  • Witters M; Department of Hand and Limb Reconstructive Surgery, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, 13005 Marseille, France.
  • Jouve E; Pharmacometry, Clinical Investigation Center-Center for Clinical Pharmacology and Therapeutic Evaluations (CIC-CPCET), Clinical Pharmacology and Pharmacovigilance Department, Hôpital de la Timone, AP-HM, 13005 Marseille, France.
  • Bec C; Therapy Cell Laboratory, Hôpital de la Conception, AP-HM, INSERM CIC BT 1409, 13005 Marseille, France.
  • Iniesta A; Department of Hand and Limb Reconstructive Surgery, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, 13005 Marseille, France.
  • Kachouh N; Department of Hand and Limb Reconstructive Surgery, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, 13005 Marseille, France.
  • Veran J; Therapy Cell Laboratory, Hôpital de la Conception, AP-HM, INSERM CIC BT 1409, 13005 Marseille, France.
  • Grimaud F; Therapy Cell Laboratory, Hôpital de la Conception, AP-HM, INSERM CIC BT 1409, 13005 Marseille, France.
  • Zavarro AC; Therapy Cell Laboratory, Hôpital de la Conception, AP-HM, INSERM CIC BT 1409, 13005 Marseille, France.
  • Fernandez R; Radiology Department, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, 13005 Marseille, France.
  • Bendahan D; Biological and Medical Magnetic Resonance Center, 13005 Marseille, France.
  • Giraudo L; Biological and Medical Magnetic Resonance Center, 13005 Marseille, France.
  • Dumoulin C; Therapy Cell Laboratory, Hôpital de la Conception, AP-HM, INSERM CIC BT 1409, 13005 Marseille, France.
  • Chagnaud C; Therapy Cell Laboratory, Hôpital de la Conception, AP-HM, INSERM CIC BT 1409, 13005 Marseille, France.
  • Casanova D; Radiology Department, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, 13005 Marseille, France.
  • Sabatier F; Department of Plastic and Reconstructive Surgery, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, 13005 Marseille, France.
  • Legré R; Therapy Cell Laboratory, Hôpital de la Conception, AP-HM, INSERM CIC BT 1409, 13005 Marseille, France.
  • Jaloux C; C2VN, INSERM 1263, INRA 1260, Aix-Marseille University, 13005 Marseille, France.
  • Magalon J; Department of Hand and Limb Reconstructive Surgery, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, 13005 Marseille, France.
J Clin Med ; 11(19)2022 Sep 29.
Article en En | MEDLINE | ID: mdl-36233654
No injection treatment has been proven to be effective in wrist osteoarthritis. When conservative measures fail, its management involves invasive surgery. Emergence of biotherapies based on adipose derived stem cells (ADSC) offers promising treatments for chondral degenerative diseases. Microfat (MF) and platelets-rich plasma (PRP) mixture, rich in growth factors and ADSC could be a minimally invasive injectable option in the treatment of wrist osteoarthritis. The aim of this uncontrolled prospective study was to evaluate the safety of a 4 mL autologous MF-PRP intra-articular injection, performed under local anesthesia. The secondary purpose was to describe the clinical and MRI results at 12 months of follow-up. Patients' data collected were: occurrence of adverse effects, Visual analog scale (VAS), Disabilities of the Arm, Shoulder and Hand score (DASH) and Patient-Rated Wrist Evaluation (PRWE) scores, wrist strength, wrist range of motion and 5-level satisfaction scale. No serious adverse event was recorded. A statistically significant decrease in pain, DASH, PRWE and force was observed at each follow-up. Our preliminary results suggest that intra-articular autologous MF and PRP injection may be a new therapeutic strategy for wrist osteoarthritis resistant to medical symptomatic treatment prior to surgical interventions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies Idioma: En Revista: J Clin Med Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies Idioma: En Revista: J Clin Med Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza