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Integrated Multi-Omics Analysis Reveals Differential Effects of Fructo-Oligosaccharides (FOS) Supplementation on the Human Gut Ecosystem.
Kato, Tamotsu; Kagawa, Masaharu; Suda, Wataru; Tsuboi, Yuuri; Inoue-Suzuki, Sayo; Kikuchi, Jun; Hattori, Masahira; Ohta, Toshiko; Ohno, Hiroshi.
Afiliación
  • Kato T; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Kanagawa 230-0045, Japan.
  • Kagawa M; Immunobiology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Kanagawa 230-0045, Japan.
  • Suda W; Institute of Nutrition Sciences, Kagawa Nutrition University, Saitama 350-0288, Japan.
  • Tsuboi Y; Laboratory for Microbiome Sciences, RIKEN Center for Integrative Medical Sciences (IMS), Kanagawa 230-0045, Japan.
  • Inoue-Suzuki S; Environmental Metabolic Analysis Research Team, RIKEN Center for Sustainable Resource Sciences (CSRS), Kanagawa 230-0045, Japan.
  • Kikuchi J; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Kanagawa 230-0045, Japan.
  • Hattori M; Immunobiology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Kanagawa 230-0045, Japan.
  • Ohta T; Environmental Metabolic Analysis Research Team, RIKEN Center for Sustainable Resource Sciences (CSRS), Kanagawa 230-0045, Japan.
  • Ohno H; Environmental Factor Analysis Laboratory, Graduate School of Medical Life Science, Yokohama City University, Kanagawa 230-0045, Japan.
Int J Mol Sci ; 23(19)2022 Oct 03.
Article en En | MEDLINE | ID: mdl-36233028
Changes in the gut ecosystem, including the microbiome and the metabolome, and the host immune system after fructo-oligosaccharide (FOS) supplementation were evaluated. The supplementation of FOS showed large inter-individual variability in the absolute numbers of fecal bacteria and an increase in Bifidobacterium. The fecal metabolome analysis revealed individual variability in fructose utilization in response to FOS supplementation. In addition, immunoglobulin A(IgA) tended to increase upon FOS intake, and peripheral blood monocytes significantly decreased upon FOS intake and kept decreasing in the post-FOS phase. Further analysis using a metagenomic approach showed that the differences could be at least in part due to the differences in gene expressions of enzymes that are involved in the fructose metabolism pathway. While the study showed individual differences in the expected health benefits of FOS supplementation, the accumulation of "personalized" knowledge of the gut ecosystem with its genetic expression may enable effective instructions on prebiotic consumption to optimize health benefits for individuals in the future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligosacáridos / Microbiota Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligosacáridos / Microbiota Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza