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Detecting Subclinical Corneal Edema Using Corneal Thickness Mapping in Patients Presenting Fuchs Endothelial Corneal Dystrophy.
Guindolet, Damien; Gemahling, Anna; Azar, Georges; Disegni, Hugo; Samie, Manal; Cochereau, Isabelle; Gabison, Eric E.
Afiliación
  • Guindolet D; From the Rothschild Foundation Hospital, Ophthalmology department, Paris, France (D.G., A.G., G.A., H.D., M.S., I.C., E.E.G.).
  • Gemahling A; From the Rothschild Foundation Hospital, Ophthalmology department, Paris, France (D.G., A.G., G.A., H.D., M.S., I.C., E.E.G.).
  • Azar G; From the Rothschild Foundation Hospital, Ophthalmology department, Paris, France (D.G., A.G., G.A., H.D., M.S., I.C., E.E.G.).
  • Disegni H; From the Rothschild Foundation Hospital, Ophthalmology department, Paris, France (D.G., A.G., G.A., H.D., M.S., I.C., E.E.G.).
  • Samie M; From the Rothschild Foundation Hospital, Ophthalmology department, Paris, France (D.G., A.G., G.A., H.D., M.S., I.C., E.E.G.).
  • Cochereau I; From the Rothschild Foundation Hospital, Ophthalmology department, Paris, France (D.G., A.G., G.A., H.D., M.S., I.C., E.E.G.); Bichat Claude-Bernard Hospital, Ophthalmology department, Paris, France (I.C., E.E.G.); Université Paris Cité, Paris, France (I.C., E.E.G).
  • Gabison EE; From the Rothschild Foundation Hospital, Ophthalmology department, Paris, France (D.G., A.G., G.A., H.D., M.S., I.C., E.E.G.); Bichat Claude-Bernard Hospital, Ophthalmology department, Paris, France (I.C., E.E.G.); Université Paris Cité, Paris, France (I.C., E.E.G). Electronic address: egabison@for.
Am J Ophthalmol ; 246: 58-65, 2023 02.
Article en En | MEDLINE | ID: mdl-36228778
PURPOSE: To determine whether local corneal thickness changes observed with optical coherence tomography (OCT) can detect subclinical corneal edema in Fuchs endothelial corneal dystrophy (FECD). SETTING: Retrospective cohort study. METHODS: A series of patients presenting FECD who underwent cataract surgery alone (45 eyes) or with concomitant Descemet membrane endothelial keratoplasty (triple procedure; 117 eyes). The study reviewed medical records, collected the preoperative corneal thickness map and calculated the differences and ratio of corneal thickness measured at 5, 7, and 9 mm from the central corneal thickness. Area under the receiver operating characteristic curves (AUCs) were calculated and thresholds were selected to obtain a specificity of 90%. RESULTS: The median difference between 5- and 2-mm corneal thickness in the supra-nasal quadrant (∆5-2mmSN) was 38 µm (interquartile range 34-46) in the cataract group and 17 µm (2-38) in the triple procedure group (P < .001). The corneal thickness ratios of supra-nasal 5- to 2-mm (R5/2mmSN) and 7- to 2-mm (R7/2mmSN) were 1.07 (1.06-1.08) and 1.15 (1.13-1.17)] in the cataract group and 1.03 (1.00-1.06) and 1.09 (1.06-1.14) in the triple procedure group (P < .001). The probability of corneal edema was increased 7-fold with ∆5-2mm SN < 27 µm (AUC = 0.76) and 9.4- and 7.4-fold with R5/2mmSN and R7/2mmSN < 1.045 (AUC = 0.77) and 1.118 (AUC = 0.76), respectively. CONCLUSIONS: Local changes in corneal thickness may be useful in detecting preclinical corneal edema, especially in patients with FECD undergoing cataract surgery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catarata / Edema Corneal / Distrofia Endotelial de Fuchs / Queratoplastia Endotelial de la Lámina Limitante Posterior Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: Am J Ophthalmol Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catarata / Edema Corneal / Distrofia Endotelial de Fuchs / Queratoplastia Endotelial de la Lámina Limitante Posterior Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: Am J Ophthalmol Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos